ArticleThe Journal of comparative neurology2012
Rearrangement of the cone mosaic in the retina of the rat model of retinitis pigmentosa.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Perceived Complexity as Normalized, Integrated, Localized Shannon Entropy.Entropy (Basel, Switzerland) · 2026Article
- Visual-tactile shape perception in Argus II Participants: The impact of prolonged device use and blindness on performance.Journal of vision · 2025Article
- Inferring Cinematic Aesthetic Biases from the Statistics of Early Movies.Entropy (Basel, Switzerland) · 2025Article
- Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.eLife · 2024Article
- Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model.bioRxiv : the preprint server for biology · 2024Article
- ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model.Scientific reports · 2021Article
- Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration.Experimental eye research · 2021Article
- Coordinated Intervention of Microglial and Müller Cells in Light-Induced Retinal Degeneration.Investigative ophthalmology & visual science · 2020Article
- Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.Experimental eye research · 2018Article
- Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina.PloS one · 2018Article
- Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.Journal of neurophysiology · 2017Article
- Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa.PloS one · 2017Article
- Inhibition of Matrix Metalloproteinase 9 Enhances Rod Survival in the S334ter-line3 Retinitis Pigmentosa Model.PloS one · 2016Article
- Article
- The effect of TIMP-1 on the cone mosaic in the retina of the rat model of retinitis pigmentosa.Investigative ophthalmology & visual science · 2014Article
- Genetically engineered pig models for human diseases.Annual review of animal biosciences · 2013Review
- Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa.Ophthalmic surgery, lasers & imaging retinaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In retinitis pigmentosa (RP), the death of cones normally follows some time after the degeneration of rods. Recently, surviving cones in RP have been studied and reported in detail. These cones undergo extensive remodeling in their morphology. Here we report an extension of the remodeling study to consider possible modifications of spatial-distribution patterns. For this purpose we used S334ter-line-3 transgenic rats, a transgenic model developed to express a rhodopsin mutation causing RP. In this study, retinas were collected at postnatal (P) days P5-30, 90, 180, and P600. We then immunostained the retinas to examine the morphology and distribution of cones and to quantify the total cone numbers. Our results indicate that cones undergo extensive changes in their spatial distribution to give rise to a mosaic comprising an orderly array of rings. These rings first begin to appear at P15 at random regions of the retina and become ubiquitous throughout the entire tissue by P90. Such distribution pattern loses its clarity by P180 and mostly disappears at P600, at which time the cones are almost all dead. In contrast, the numbers of cones in RP and normal conditions do not show significant differences at stages as late as P180. Therefore, rings do not form by cell death at their centers, but by cone migration. We discuss its possible mechanisms and suggest a role for hot spots of rod death and the remodeling of Müller cell process into zones of low density of photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.