ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Effects of colchicine on the prevention of AF recurrence after atrial ablation: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Effect of corticosteroids on atrial fibrillation after catheter ablation: a meta-analysisJournal of Zhejiang University. Science. BPooled it
- Colchicine in prevention of atrial fibrillation following cardiac surgery: systematic review and meta-analysis.Indian journal of pharmacologyPooled it
- Comparative Effectiveness of Antiarrhythmic Drugs on Early Atrial Tachyarrhythmias in the Blanking Period After Atrial Fibrillation Catheter Ablation.Journal of arrhythmia · 2026Article
- The clinical pathophysiology of atrial fibrillation: outstanding questions from bedside to bench and back.Physiological reviews · 2026Review
- Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes.Experimental physiology · 2026Review
- Early recurrence of atrial arrhythmia following catheter ablation of atrial tachycardia consecutive to ablation of atrial fibrillation using the updated blanking period.Heart rhythm O2 · 2026Article
- Machine learning models of inflammatory markers used in the prediction of early and late atrial fibrillation recurrence in overweight and obese patients after catheter ablation.Cardiology journal · 2026Article
- Comparative Predictive Value of Nine Composite Inflammatory Markers for Atrial Fibrillation Recurrence After Catheter Ablation.Journal of inflammation research · 2026Article
- Controversy: the blanking period after atrial fibrillation ablation is needed and should be maintained.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Biomarkers of postoperative cardiac surgery-associated acute kidney injury: Narrowing the field.JTCVS open · 2025Article
- Beyond Pulmonary Vein Reconnection: Exploring the Dynamic Pathophysiology of Atrial Fibrillation Recurrence After Catheter Ablation.Journal of clinical medicine · 2025Review
- A new scoring system to predict the risk of late recurrence in extended follow-up after atrial fibrillation catheter ablation: APCEL score.Journal of arrhythmia · 2025Article
- Long-term outcomes of concomitant Cox-Maze III procedure in patients with aortic valve diseases and preoperative atrial fibrillation.Journal of thoracic disease · 2025Article
- Risk factors for the recurrence of atrial fibrillation after catheter ablation: a meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- Interactions between atrial fibrosis and inflammation in atrial fibrillation.Frontiers in cardiovascular medicine · 2025Review
- Incidence and prognostic significance of atrial fibrillation in patients with tako-tsubo syndrome-systematic review and meta-analysis.Caspian journal of internal medicine · 2025Review
- 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Journal of arrhythmia · 2024Article
- 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Factors predicting the recurrence of atrial fibrillation after catheter ablation: A review.Heliyon · 2024Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of oxidative stress after radiofrequency ablation of atrial fibrillation (AF) has not yet been well characterized. We sought to evaluate the time course of biomarkers of oxidative stress and inflammation after AF ablation and their association with clinical variables.
methodsThirty consecutive patients (57.9 ± 1.7 years, 63% males) with paroxysmal AF underwent pulmonary vein isolation and ablation of complex fractionated atrial electrograms. Biomarkers were determined in blood samples before ablation and 6 h, 1, 2, 7, 30, 90 and 180 days post-ablation.
resultsThe pro-oxidant enzyme myeloperoxidase and oxidized low-density lipoprotein reflecting oxidant damage of lipoproteins increased 2.9 ± 0.2-fold and 1.2 ± 0.1-fold, respectively, and were significantly up-regulated until day 2 post-ablation. The anti-oxidant enzyme copper/zinc superoxide dismutase did not change significantly. Inflammatory markers significantly increased (high-sensitivity C-reactive protein (hs-CRP): 41 ± 8-fold; interleukin-6: 4.4 ± 0.7-fold) for 7 and 2 days, respectively. The increase of myeloperoxidase and hs-CRP was interrelated and both predicted early recurrence of AF within the first post-ablation week (both p < 0.05). The increase of both markers was associated with the amount of delivered radiofrequency energy (p < 0.05). The up-regulation of hs-CRP correlated with troponin T (p = 0.008), while myeloperoxidase and troponin T were borderline associated (p = 0.054). However, the oxidative and inflammatory responses did not predict long-term ablation outcome (p > 0.05).
conclusionsMarkers of oxidative stress showed a significant up-regulation during the first 2 days after AF ablation. Their up-regulation was linked to inflammation, delivered radiofrequency energy, and early recurrence of AF, but did not predict long-term ablation outcome.
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