Evidence map›Paper›PMID 22102085›Full record

ArticleThe Journal of comparative neurology2012

The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals.

Alain C Burette, Richard J Weinberg, Patrick Sassani, Natalia Abuladze, Liyo Kao, Ira Kurtz

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. The role of NaPflugers Archiv : European journal of physiology · 2024
    Review
  2. Article
  3. Article
  4. Decreased Brain pH and Pathophysiology in Schizophrenia.International journal of molecular sciences · 2021
    Review
  5. Deletion of the Na/HCOScientific reports · 2019
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Cation-coupled bicarbonate transporters.Comprehensive Physiology · 2014
    Review
  11. Review
  12. Anion transport and GABA signaling.Frontiers in cellular neuroscience · 2013
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alain C BuretteDepartment of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. alain.burette@gmail.com
Richard J Weinberg
Patrick Sassani
Natalia Abuladze
Liyo Kao
Ira Kurtz
University of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · US

Funding

The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
The Supramolecular Architecture of the Postsynaptic DensityR01NS039444 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERG, RICHARD J · 2000 to 2021
$6.1M
BIOLOGY OF SODIUM BICARBONATE TRANSPORTR01DK058563 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KURTZ, IRA · 2001 to 2011
$3.1M
GLUTAMATE RECEPTORS AND THALAMOCORTICAL TRANSMISSIONR01NS035527 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERG, RICHARD J · 1998 to 2012
$2.8M
NIDDK NIH HHS DK058563NIDDK NIH HHS DK077162NIDDK NIH HHS R01 DK058563NIDDK NIH HHS R01 DK077162NINDS NIH HHS NS35527NINDS NIH HHS NS39444NINDS NIH HHS R01 NS035527NINDS NIH HHS R01 NS039444
6 · The paper itself

Abstract

The sodium-driven chloride/bicarbonate exchanger (NDCBE), a member of the SLC4 family of bicarbonate transporters, was recently found to modulate excitatory neurotransmission in hippocampus. By using light and electron microscopic immunohistochemistry, we demonstrate here that NDCBE is expressed throughout the adult rat brain, and selectively concentrates in presynaptic terminals, where it is closely associated with synaptic vesicles. NDCBE is in most glutamatergic axon terminals, and is also present in the terminals of parvalbumin-positive γ-aminobutyric acid (GABA)ergic cells. These findings suggest that NDCBE can regulate glutamatergic transmission throughout the brain, and point to a role for NDCBE as a possible regulator of GABAergic neurotransmission.

Indexed as

AnimalsChloride-Bicarbonate AntiportersGABAergic NeuronsHippocampusImmunohistochemistryMaleMicroscopy, Electron, TransmissionPresynaptic TerminalsRatsRats, Sprague-DawleySynaptic TransmissionChloride-Bicarbonate AntiportersSLC4A8 protein, RAT

Identifiers

PMID22102085
PMCPMC3856893
OpenAlexW1997332429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.