ArticleDiabetologia2012
Diabetes is associated with impairment of uterine contractility and high Caesarean section rate.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association of bipolar disorder and schizophrenia in women with risk of gestational diabetes: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Maternal body mass index and post-term birth: a systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Diabetes mellitus: an independent predictor of duration of prostaglandin labor induction.Journal of perinatology : official journal of the California Perinatal Association · 2017Trial
- Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial.Public health nutrition · 2016Trial
- Association between serum 25-hydroxyvitamin D [25(OH)D] levels and vaginal delivery in pregnant women: an observational case-control study from Türkiye.Frontiers in medicine · 2026Article
- Risk Factors for a Primary Cesarean Delivery in Pregnancies Complicated by Pregestational Diabetes.International journal of women's health · 2026Article
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.Molecular metabolism · 2026Article
- Pregestational Diabetes and Duration of Active Labour Compared With Non-Diabetic Women: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Maternal and neonatal complications of pregnant women with bipolar disorder: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Assessment of the hypoglycemic effect ofCurrent research in physiology · 2025Article
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.bioRxiv : the preprint server for biology · 2024Article
- Predictive Factors for Successful Cervical Ripening among Women with Gestational Diabetes Mellitus at Term: A Prospective Study.Journal of clinical medicine · 2023Article
- Gestational diabetes mellitus and time in active labor: A population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2023Article
- High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.Frontiers in endocrinology · 2023Article
- Forces Involved with Labor and Delivery-A Biomechanical Perspective.Annals of biomedical engineering · 2021Review
- Influence of high glucose in the expression of miRNAs and IGF1R signaling pathway in human myometrial explants.Archives of gynecology and obstetrics · 2021Article
- Fetal and Placental Weight in Pre-Gestational Maternal Obesity (PGMO) vs. Excessive Gestational Weight Gain (EGWG)-A Preliminary Approach to the Perinatal Outcomes in Diet-Controlled Gestational Diabetes Mellitus.Journal of clinical medicine · 2020Article
- Uterine Dysfunction in Diabetic Mice: The Role of Hydrogen Sulfide.Antioxidants (Basel, Switzerland) · 2020Article
- Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development.Journal of visualized experiments : JoVE · 2018Article
- Seipin deficiency leads to defective parturition in mice.Biology of reproduction · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe prevalence of births worldwide complicated by diabetes mellitus is increasing. In the UK, for example, <25% of diabetic women have a non-instrumental vaginal delivery. Strikingly, more than half the Caesarean sections (CS) in these patients are non-elective, but the reasons for this are not understood. We have tested the hypothesis that poor myometrial contractility as a consequence of the disease contributes to this high CS rate.
methodsWe compared spontaneous, high K depolarisation and oxytocin-induced contractions from diabetic and matched control patients having an elective CS. To investigate the mechanism of any differences we measured intracellular Ca, and performed western blotting and compared the tissues histologically.
resultsThere was significantly decreased contraction amplitude and duration in uteri from diabetic compared with control patients, even when possible confounders such as BMI were analysed. Reduced intracellular calcium signals and expression of calcium entry channels were found in uteruses from diabetic patients, which, along with a reduction in muscle content found on histological examination, could explain the reduced force. Myometrium from diabetic patients was responsive to oxytocin, but still did not reach the levels found in non-diabetic patients. CONCLUSIONS/INTERPRETATIONS: These are the first data investigating myometrium in diabetic patients and they support the hypothesis that there is poorer contractility even in the presence of oxytocin. The underlying mechanism is related to reduced Ca channel expression and intracellular calcium signals and a decrease in muscle mass. We conclude that these factors significantly contribute to the increased emergency CS rate in diabetic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.