ArticleJournal of structural and functional genomics2012
The ESFRI Instruct Core Centre Frankfurt: automated high-throughput crystallization suited for membrane proteins and more.
Article in Journal of structural and functional genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Crystal search - feasibility study of a real-time deep learning process for crystallization well images.Acta crystallographica. Section A, Foundations and advances · 2023Article
- The structure of theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- A standardized technique for high-pressure cooling of protein crystals.Acta crystallographica. Section D, Structural biology · 2017Article
- Pseudomonas stutzeri as an alternative host for membrane proteins.Microbial cell factories · 2017Article
- Structural genomics studies of human caries pathogen Streptococcus mutans.Journal of structural and functional genomics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structure determination of membrane proteins and membrane protein complexes is still a very challenging field. To facilitate the work on membrane proteins the Core Centre follows a strategy that comprises four labs of protein analytics and crystal handling, covering mass spectrometry, calorimetry, crystallization and X-ray diffraction. This general workflow is presented and a capacity of 20% of the operating time of all systems is provided to the European structural biology community within the ESFRI Instruct program. A description of the crystallization service offered at the Core Centre is given with detailed information on screening strategy, screens used and changes to adapt high throughput for membrane proteins. Our aim is to constantly develop the Core Centre towards the usage of more efficient methods. This strategy might also include the ability to automate all steps from crystallization trials to crystal screening; here we look ahead how this aim might be realized at the Core Centre.
Indexed as
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22101889What OpenQuestion holds
Registered trials
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