ArticleMammalian genome : official journal of the International Mammalian Genome Society2012
Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery.Nature protocols · 2023Review
- A Set of Dysregulated Target Genes to Reduce Neuroinflammation at Molecular Level.International journal of molecular sciences · 2022Article
- Computational Analysis of the Global Effects ofGenes · 2020Article
- Emerging Role of LY6E in Virus-Host Interactions.Viruses · 2019Review
- The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- CD4-Dependent Modulation of HIV-1 Entry by LY6E.Journal of virology · 2019Article
- LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step.Nature communications · 2018Article
- Interferon-inducible LY6E Protein Promotes HIV-1 Infection.The Journal of biological chemistry · 2017Article
- Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge.PloS one · 2016Article
- The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.Genome research · 2014Article
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Authors and funding
2 authors.
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Abstract
Strain-specific differences in susceptibility to mouse adenovirus type 1 (MAV-1) are linked to the quantitative trait locus Msq1 on mouse chromosome 15. This region contains 14 Ly6 or Ly6-related genes, many of which are known to be expressed on the surface of immune cells, suggesting a possible role in host defense. We analyzed these genes for polymorphisms between MAV-1-susceptible and MAV-1-resistant inbred mouse strains. Sequencing of cDNAs identified 12 coding-region polymorphisms in 2010109I03Rik, Ly6e, Ly6a, Ly6c1, and Ly6c2, six of which were nonsynonymous and five of which were previously unlisted in dbSNP Build 132. We also clarified sequence discrepancies in GenBank for the coding regions of I830127L07Rik and Ly6g. Additionally, Southern blotting revealed size polymorphisms within the DNA regions of Ly6e, Ly6a, and Ly6g. Collectively, these genetic variations have implications for the structure, function, and/or expression of Ly6 and Ly6-related genes that may contribute to the observed strain-specific differences in susceptibility to MAV-1.
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