ArticleEuropean radiology2012
MR spectroscopy and micro-CT in evaluation of osteoporosis model in rabbits: comparison with histopathology.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of zoledronic acid on vertebral marrow adiposity in postmenopausal osteoporosis assessed by MR spectroscopy.Skeletal radiology · 2015Trial
- Longitudinal assessment of oxytocin efficacy on bone and bone marrow fat masses in a rabbit osteoporosis model through 3.0-T magnetic resonance spectroscopy and micro-CT.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Article
- The q-Dixon sequence for MRI predicts osteoporotic vertebral compression fractures.Frontiers in endocrinology · 2025Article
- mDIXON-Quant technique diagnostic accuracy for assessing bone mineral density in male adult population.BMC musculoskeletal disorders · 2023Article
- Lumbar Spine Bone Mineral Density Measurement: Comparison of Dual-Energy X-Ray Absorptiometry and Fat Content Evaluation by Dixon Chemical Shift MRI.International journal of general medicine · 2022Article
- Opportunistic osteoporosis screening in multi-detector CT images using deep convolutional neural networks.European radiology · 2021Article
- Effect of diode laser biostimulation compared to Teriparatide on induced osteoporosis in rats: an animal study from Egypt.International journal of clinical and experimental pathology · 2020Article
- Rabbit as model for osteoporosis research.Journal of bone and mineral metabolism · 2019Review
- Simultaneous Estimation of the Fat Fraction and R₂Korean journal of radiology · 2019Article
- Bone marrow adipose amount influences vertebral bone strength.Experimental and therapeutic medicine · 2019Article
- An Ovariectomy-Induced Rabbit Osteoporotic Model: A New Perspective.Asian spine journal · 2018Article
- Comparison of semi-quantitative and quantitative dynamic contrast-enhanced MRI evaluations of vertebral marrow perfusion in a rat osteoporosis model.BMC musculoskeletal disorders · 2017Article
- Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD.Scientific reports · 2017Article
- [Effect of resveratrol on peak bone mass in growing rats].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Article
- The functional mechanism of simvastatin in experimental osteoporosis.Journal of bone and mineral metabolism · 2016Article
- Contributions of fat mass and fat distribution to hip bone strength in healthy postmenopausal Chinese women.Journal of bone and mineral metabolism · 2015Article
- Time Related Changes of Mineral and Collagen and Their Roles in Cortical Bone Mechanics of Ovariectomized Rabbits.PloS one · 2015Article
- Temporal changes of microarchitectural and mechanical parameters of cancellous bone in the osteoporotic rabbit.BioMed research international · 2015Article
- The temporal characterization of marrow lipids and adipocytes in a rabbit model of glucocorticoid-induced osteoporosis.Skeletal radiology · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore the evidence of regular alteration of bone quality in osteoporosis dynamically examined by MRS and micro-CT, comparing with histopathology.
methodsForty rabbits were allocated into two groups. Group A were used as sham. Group B underwent bilateral ovariectomy (OVX) combined with daily intramuscular methylprednisolone, underwent MR spectroscopy, micro-CT, and histopathology of L5 at 2, 4, 8, and 10 weeks after operation.
resultsFat fraction as shown by MRS in Group B was significantly increased over the time course of osteoporosis development with significant difference between two groups at 4, 8, and 10 weeks after OVX. Continuous deterioration of cancellous bone architecture in Group B, was first detected at week 4. FF value in group B correlated with micro-CT parameters. Marrow fat as measured by MR and CT was positively correlated with both the mean density and diameter of adipocytes (both of which increased over time).
conclusionsMarrow adipogenesis occurs in synchrony with deterioration of trabecular microarchitecture.MRS may be valuable to assess the pathophysiological changes of bone marrow in osteoporosis in early stage. KEY POINTS: MRS revealed gradually increasing bone marrow fat in rabbits rendered osteoporotic. Marrow adipogenesis occurs in synchrony with deterioration of trabecular microarchitecture. Pathology revealed an early increase in number of marrow adipocytes in osteoporosis. MRS may help assess early pathophysiological bone marrow changes in osteoporosis.
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