ReviewImmunologic research2011
Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.
Review in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- In-silico design of a multi-epitope vaccine candidate against Strongyloides stercoralis.BMC infectious diseases · 2026Article
- UnderstandingToxicology reports · 2024Review
- Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis.PLoS neglected tropical diseases · 2024Article
- Strongyloidiasis.Nature reviews. Disease primers · 2024Review
- Review
- Host genetic backgrounds: the key to determining parasite-host adaptation.Frontiers in cellular and infection microbiology · 2023Review
- Eosinophils and Neutrophils Eliminate MigratingFrontiers in immunology · 2021Article
- Diagnostic Potential of an IgE-ELISA in Detecting Strongyloidiasis.The American journal of tropical medicine and hygiene · 2020Article
- IL-33 facilitates rapid expulsion of the parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation.PLoS pathogens · 2020Article
- Human T-cell Leukemia Virus Type 1 andPathogens (Basel, Switzerland) · 2020Review
- Systemic profile of immune factors in an elderly Italian population affected by chronic strongyloidiasis.Parasites & vectors · 2020Article
- Host Immunity and Inflammation to Pulmonary Helminth Infections.Frontiers in immunology · 2020Review
- Advances in the Molecular and Cellular Biology ofCurrent tropical medicine reports · 2019Article
- Review
- Regulatory T cells and IgE expression in duodenal mucosa of Strongyloides stercoralis and human T lymphotropic virus type 1 co-infected patients.PLoS neglected tropical diseases · 2019Article
- Article
- Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.PLoS neglected tropical diseases · 2018Article
- Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory.Scientific reports · 2018Article
- Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins inFrontiers in immunology · 2018Article
- Anthelmintic Therapy Modifies the Systemic and Mycobacterial Antigen-Stimulated Cytokine Profile in Helminth-Latent Mycobacterium tuberculosis Coinfection.Infection and immunity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in the mechanisms used by the immune response to kill the parasite and that a vaccine with a single antigen may be suitable as a prophylactic vaccine to prevent human strongyloidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.