ArticleJournal of molecular evolution2011
Evaluating the impact of post-mortem damage in ancient DNA: a theoretical approach.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Patterns of aDNA damage through time and environments-lessons from herbarium specimens.GigaScience · 2026Article
- Article
- Phylogenetic comparative analysis of functional morphology sheds light on the evolution of seasonal migration in nightingale-thrushes (Turdidae: Catharus).Scientific reports · 2025Article
- A Post-Mortem Molecular Damage Profile in the Ancient Human Mitochondrial DNA.Molecular ecology resources · 2025Article
- Demographic history and genetic variation of the Armenian population.American journal of human genetics · 2025Article
- Advancements and Challenges in Ancient DNA Research: Bridging the Global North-South Divide.Genes · 2023Review
- Article
- Temporal patterns of damage and decay kinetics of DNA retrieved from plant herbarium specimens.Royal Society open science · 2016Article
- Impacts of low coverage depths and post-mortem DNA damage on variant calling: a simulation study.BMC genomics · 2015Article
- Horizontal transfer of short and degraded DNA has evolutionary implications for microbes and eukaryotic sexual reproduction.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- The half-life of DNA in bone: measuring decay kinetics in 158 dated fossils.Proceedings. Biological sciences · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growth of ancient DNA research has offered exceptional opportunities and raised great expectations, but has also presented some considerable challenges. One of the ongoing issues is the impact of post-mortem damage in DNA molecules. Nucleotide alterations and DNA strand breakages lead to a significant decrease in the quantity of DNA molecules of useful length in a sample and to errors in the final DNA sequences obtained. We present a model of age-dependent DNA damage and quantify the influence of that damage on subsequent steps in the sequencing process, including the polymerase chain reaction and cloning. Calculations using our model show that deposition conditions, rather than the age of a sample, have the greatest influence on the level of DNA damage. In turn, this affects the probability of interpreting an erroneous (possessing damage-derived mutations) sequence as being authentic. We also evaluated the effect of post-mortem damage on real data sets using a Bayesian phylogenetic approach. According to our study, damage-derived sequence alterations appear to have little impact on the final DNA sequences. This indicates the effectiveness of current methods for sequence authentication and validation.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.