ReviewCell cycle (Georgetown, Tex.)2011
Keeping chromatin quiet: how nucleosome remodeling restores heterochromatin after replication.
Review in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- SMARCAD1-mediated active replication fork stability maintains genome integrity.Science advances · 2021Article
- On the relations of phase separation and Hi-C maps to epigenetics.Royal Society open science · 2020Article
- Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.Nature communications · 2020Article
- Chromatin remodeling and mismatch repair: Access and excision.DNA repair · 2020Review
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- Review
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- Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain.Scientific reports · 2017Article
- Chromatin remodeling modulates radiosensitivity of the daughter cells derived from cell population exposed to low- and high-LET irradiation.Oncotarget · 2017Article
- The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.Nucleus (Austin, Tex.) · 2017Review
- Repair of DNA Double-Strand Breaks in Heterochromatin.Biomolecules · 2016Review
- Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals.Journal of biosciences · 2016Review
- Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.Scientific reports · 2016Article
- SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation.Scientific reports · 2016Article
- DNA methylation and differential gene regulation in photoreceptor cell death.Cell death & disease · 2014Article
- Chromatin dynamics: interplay between remodeling enzymes and histone modifications.Biochimica et biophysica acta · 2014Review
- Chromatin remodeling: a collaborative effort.Nature structural & molecular biology · 2014Article
- Epigenetic control of mobile DNA as an interface between experience and genome change.Frontiers in genetics · 2014Review
- Role of epigenetic modulation for the treatment of sarcoma.Current treatment options in oncology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Disruption of chromatin organization during replication poses a major challenge to the maintenance and integrity of genome organization. It creates the need to accurately reconstruct the chromatin landscape following DNA duplication but there is little mechanistic understanding of how chromatin based modifications are restored on newly synthesized DNA. ATP-dependent chromatin remodeling activities serve multiple roles during replication and recent work underscores their requirement in the maintenance of proper chromatin organization. A new component of chromatin replication, the SWI/SNF-like chromatin remodeler SMARCAD1, acts at replication sites to facilitate deacetylation of newly assembled histones. Deacetylation is a pre-requisite for the restoration of epigenetic signatures in heterochromatin regions following replication. In this way, SMARCAD1, in concert with histone modifying activities and transcriptional repressors, reinforces epigenetic instructions to ensure that silenced loci are correctly perpetuated in each replication cycle. The emerging concept is that remodeling of nucleosomes is an early event imperative to promote the re-establishment of histone modifications following DNA replication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.