ReviewExperimental neurology2013
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.
Review in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy.Neurology · 2014Trial
- Association of CYP3A4*1B and SLC6A11 Genetic Variants with Epilepsy Risk And Antiepileptic Drug Response in an Iraqi Population.Molecular neurobiology · 2025Article
- Molecular mechanisms of neurosteroids in temporal lobe epilepsy: current insights and therapeutic perspectives.Molecular biology reports · 2025Review
- Progesterone modulates neuronal excitability bidirectionally.Neuroscience letters · 2021Review
- Investigating the Anticonvulsant Properties of Aqueous Ethanolic Extracts of the Leaves, Roots, and Fruits ofAdvances in pharmacological and pharmaceutical sciences · 2021Article
- Successful Experience of Cyclic Progesterone Supplementation in Catamenial Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Reduced neurosteroid potentiation of GABAAnnals of clinical and translational neurology · 2020Article
- Neurosteroid regulation of GABABrain research · 2019Review
- Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis.Journal of neuroinflammation · 2018Article
- A novel therapeutic approach for treatment of catamenial epilepsy.Neurobiology of disease · 2018Article
- Neurosteroid-sensitive δ-GABAEpilepsia · 2017Article
- Influence of Menstrual Cycle and Oral Contraceptive Phase on Spinal Excitability.PM & R : the journal of injury, function, and rehabilitation · 2016Article
- Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.Experimental neurology · 2015Article
- Seizures and epilepsy: an overview for neuroscientists.Cold Spring Harbor perspectives in medicine · 2015Review
- Sex differences in the neurobiology of epilepsy: a preclinical perspective.Neurobiology of disease · 2014Review
- Regulating hippocampal hyperexcitability through GABAB Receptors.Physiological reports · 2014Article
- Article
- Sex and hormonal influences on seizures and epilepsy.Hormones and behavior · 2013Review
- Molecular pathways controlling inhibitory receptor expression.Epilepsia · 2012Review
- A mouse kindling model of perimenstrual catamenial epilepsy.The Journal of pharmacology and experimental therapeutics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.