ArticleNeurotoxicology2012
Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus.
Article in Neurotoxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 99 citations in OpenAlex.
- Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.Journal of the Endocrine Society · 2026Article
- Postnatal maternal care impacts hypothalamicbioRxiv : the preprint server for biology · 2025Article
- Transcriptomic analysis of effects of developmental PCB exposure in the hypothalamus of female rats.Molecular and cellular endocrinology · 2025Article
- Neuroendocrine and Developmental Impacts of Early Life Exposure to EDCs.Journal of the Endocrine Society · 2024Article
- Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Toxicological Impact of Bisphenol A on Females' Reproductive System: Review Based on Experimental and Epidemiological Studies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Different types of bisphenols alter ovarian steroidogenesis: Special attention to BPA.Heliyon · 2023Article
- Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.Molecular and cellular endocrinology · 2022Article
- Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development.Frontiers in pharmacology · 2022Review
- Bisphenol A and Its Analogues Deteriorate the Hormones Physiological Function of the Male Reproductive System: A Mini-Review.Biomedicines · 2021Review
- Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat.Environmental health perspectives · 2021Article
- A Review of Recent Studies on Bisphenol A and Phthalate Exposures and Child Neurodevelopment.International journal of environmental research and public health · 2021Review
- Cellular and molecular features of EDC exposure: consequences for the GnRH network.Nature reviews. Endocrinology · 2021Review
- Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study.Endocrinology · 2020Article
- Achieving CLARITY on bisphenol A, brain and behaviour.Journal of neuroendocrinology · 2020Review
- Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.Nature reviews. Endocrinology · 2020Review
- Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice.Environmental health perspectives · 2019Article
- Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study.Neurotoxicology · 2019Article
- CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems.Basic & clinical pharmacology & toxicology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Developmental exposure to Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been purported to adversely impact reproductive function in female rodents. Because neonatal life is a critical window for the sexual dimorphic organization of the hypothalamic-pituitary-gonadal (HPG) axis, interference with this process could underlie compromised adult reproductive physiology. The goal of the present study was to determine if neonatal BPA exposure interferes with sex specific gene expression of estrogen receptor alpha (ERα), ER beta (ERβ) and kisspeptin (Kiss1) in the anterior and mediobasal hypothalamus. Long Evans (LE) neonatal rats were exposed to vehicle, 10μg estradiol benzoate (EB), 50mg/kg BPA or 50μg/kg BPA by subcutaneous injection daily from postnatal day 0 (PND 0) to PND 2. Gene expression was assessed by in situ hybridization on PNDs 4 and 10. Within the anterior hypothalamus ERα expression was augmented by BPA in PND 4 females, then fell to male-typical levels by PND 10. ERβ expression was not altered by BPA on PND 4, but significantly decreased or eliminated in both sexes by PND 10. Kiss1 expression was diminished by BPA in the anterior hypothalamus, especially in females. There were no significant impacts of BPA in the mediobasal hypothalamus. Collectively, BPA effects did not mirror those of EB. The results show that neonatal hypothalamic ER and Kiss1 expression is sensitive to BPA exposure. This disruption may alter sexually dimorphic hypothalamic organization and underlie adult reproductive deficiencies. Additionally, the discordant effects of EB and BPA indicate that BPA likely disrupts hypothalamic organization by a mechanism other than simply acting as an estrogen mimic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.