ReviewNeurochemistry international2012
Blood-brain barrier in acute liver failure.
Review in Neurochemistry international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Liver Organoids: From Disease Modelling to Regenerative Medicine.Cell proliferation · 2026Review
- Glutamine and Albumin Levels in Cerebrospinal Fluid Are Correlated with Neurological Severity in an Experimental Model of Acute Hepatic Encephalopathy.Metabolites · 2025Article
- Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats.Metabolic brain disease · 2024Article
- Increased IgA-mediated responses to the gut paracellular pathway and blood-brain barrier proteins predict delirium due to hip fracture in older adults.Frontiers in neurology · 2024Article
- miRNA-ome plasma analysis unveils changes in blood-brain barrier integrity associated with acute liver failure in rats.Fluids and barriers of the CNS · 2023Article
- Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage.Brain sciences · 2021Article
- The neurogliovascular unit in hepatic encephalopathy.JHEP reports : innovation in hepatology · 2021Review
- Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.Neurochemistry international · 2018Article
- Altered Function and Expression of ABC Transporters at the Blood-Brain Barrier and Increased Brain Distribution of Phenobarbital in Acute Liver Failure Mice.Frontiers in pharmacology · 2018Article
- Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure.Journal of virology · 2016Article
- Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats.Acta pharmacologica Sinica · 2016Article
- Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation.Journal of clinical and experimental hepatology · 2015Review
- Article
- Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats.World journal of hepatology · 2014Article
- Morphological changes of cortical pyramidal neurons in hepatic encephalopathy.BMC neuroscience · 2014Article
- Pathophysiology of cerebral oedema in acute liver failure.World journal of gastroenterology · 2013Review
- TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema.Metabolic brain disease · 2013Review
- Alterations of blood-brain barrier and associated factors in acute liver failure.Gastroenterology research and practice · 2013Article
- Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Brain edema remains a challenging obstacle in the management of acute liver failure (ALF). Cytotoxic mechanisms associated with brain edema have been well recognized, but evidence for vasogenic mechanisms in the pathogenesis of brain edema in ALF has been lacking. Recent reports have not only shown a role of matrix metalloproteinase-9 in the pathogenesis of brain edema in experimental ALF but have also found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. This article reviews and explores the role of the paracellular tight junction proteins in the increased selective BBB permeability that leads to brain edema in ALF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.