ArticleBone2012
Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model.
Article in Bone, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Mechanistic Potentials of Natural Herbal Medicines (NHMs) in Promoting Bone Regeneration: A Comprehensive Review.Current drug metabolism · 2026Review
- A mathematical model of metacarpal subchondral bone adaptation, microdamage and repair in racehorses.Journal of the Royal Society, Interface · 2025Article
- Modelling the Effects of Growth and Remodelling on the Density and Structure of Cancellous Bone.Bulletin of mathematical biology · 2024Article
- Article
- A review of mathematical modeling of bone remodeling from a systems biology perspective.Frontiers in systems biology · 2024Article
- Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability.Frontiers in bioengineering and biotechnology · 2023Article
- Direct Assessment of Rabbit Cortical Bone Basic Multicellular Unit Longitudinal Erosion Rate: A 4D Synchrotron-Based Approach.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing.PLoS computational biology · 2022Article
- Modeling the Human Bone-Tumor Niche: Reducing and Replacing the Need for Animal Data.JBMR plus · 2020Review
- Toward a Mathematical Modeling of Diseases' Impact on Bone Remodeling: Technical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Pathologic conditions of hard tissue: role of osteoclasts in osteolytic lesion.Histochemistry and cell biology · 2018Review
- Osteoblast migration in vertebrate bone.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Bone fracture healing in mechanobiological modeling: A review of principles and methods.Bone reports · 2017Review
- Bone remodeling as a spatial evolutionary game.Journal of theoretical biology · 2017Article
- Article
- Role of mathematical modeling in bone fracture healing.BoneKEy reports · 2012Review
- Computational modeling of bone fracture non-unions: four clinically relevant case studies.In silico cell and tissue scienceReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the renewal of osteoclast nuclei by cell fusion. All these features are shown to strongly influence the geometrical properties of the developing resorption cavity including its size, shape and progression rate, and are also shown to influence the distribution, resorption pattern and trajectories of individual osteoclasts within the BMU. We demonstrate that for certain parameter combinations, resorption cavity shapes can be recovered from the computational model that closely resemble resorption cavity shapes observed from microCT imaging of human cortical bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.