ArticleJournal of endodontics2011
Direct contact with mineral trioxide aggregate activates and differentiates human dental pulp cells.
Article in Journal of endodontics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 94 citations in OpenAlex.
- Histopathological and immunohistochemical characterization of pulp tissue reaction to ACTIVA BioACTIVE base/liner in primary teeth pulpotomy: a randomized clinical trial.BMC oral health · 2025Trial
- MTA does not induce oxidative stress and apoptotic response, or calcium-related cellular stress and preserves extracellular matrix homeostasis.Molecular biology reports · 2026Article
- Differential Expression of S100A Genes in hDPSCs Following Stimulation with Two Hydraulic Calcium Silicate Cements: A Laboratory Investigation.Journal of functional biomaterials · 2026Article
- An In Vitro Tube Model for Cell Biocompatibility Study of Capping Materials for Regenerative Endodontics.Journal of endodontics · 2025Article
- Comparative evaluation of cytotoxic effects of a new biomaterial nanohydroxyapatite-lactoferrin, nanohydroxyapatite, mineral trioxide aggregate, and calcium-enriched mixture on human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2025Article
- Long-Term Evaluation of Pulp Vitality Preservation in Direct and Indirect Pulp Capping: A Retrospective Clinical Study.Journal of clinical medicine · 2024Article
- Article
- Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study.Clinical and experimental dental research · 2024Article
- Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements.BMC oral health · 2024Article
- Comparative Outcomes of Pulpotomy in Mature Molars with Irreversible Pulpitis: A Non-Randomized Trial Evaluating Calcified and Non-Calcified Pulp Chambers.Iranian endodontic journal · 2024Article
- Article
- Combined effects of bone morphogenetic protein-7 and mineral trioxide aggregate on the proliferation, migration, and differentiation of human dental pulp stem cells.Journal of applied oral science : revista FOB · 2022Article
- Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing.Clinical oral investigations · 2021Article
- Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars.International journal of environmental research and public health · 2021Article
- Effect of Tricalcium Silicate on Direct Pulp Capping: Experimental Study in Rats.European journal of dentistry · 2021Article
- Cytotoxicity assessment of Bio-C Repair Íon+: A new calcium silicate-based cement.Journal of dental research, dental clinics, dental prospects · 2021Article
- The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review.Biomaterial investigations in dentistry · 2020Review
- Melatonin as an Agent for Direct Pulp-Capping Treatment.International journal of environmental research and public health · 2020Article
- Odontoblast-like Cytodifferentiation of Dental Stem Cells: A Review.Iranian endodontic journal · 2020Review
- Response of stem cells from human exfoliated deciduous teeth (SHED) to three bioinductive materials - An in vitro experimental study.The Saudi dental journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionMineral trioxide aggregate (MTA) is routinely used for pulp-capping procedures. However, little is known about its direct interaction with the cells or whether MTA is capable of releasing soluble factors that could help in differentiating cells. There have been no previous studies showing this aspect of MTA. Hence, the aim of this study was to determine whether direct contact of the cells with MTA was necessary to help differentiate the pulp cells into odontoblast-like cells.
methodsHuman dental pulp cells were cultured on gray MTA, either in direct contact or away from the cells on a cell culture insert, and the levels of gene expression, secretion of vascular endothelial growth factor (VEGF), and the rates of cell proliferation were analyzed.
resultsMTA when placed in direct contact with the cells promoted up-regulated the expression of important odontoblastic genes like osteocalcin and dentin sialoprotein, thereby showing that direct contact of the cells with the MTA is necessary to promote differentiation of the pulp cells into odontoblast-like cells, which in turn are responsible for dentin bridge formation. MTA also induced an increase in the secretion of VEGF when placed in direct contact with the cells.
conclusionsOverall, our study supports the fact that direct contact of the cells with the MTA is necessary to help differentiate them into odontoblast-like cells, which in turn will lead to a successful treatment outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.