Evidence map›Paper›PMID 22099522›Full record

Trial reportThe Journal of pediatrics2012

Neurodevelopmental outcomes in infants requiring resuscitation in developing countries.

Waldemar A Carlo, Shivaprasad S Goudar, Omrana Pasha, Elwyn Chomba, Elizabeth M McClure, Fred J Biasini, Jan L Wallander, Vanessa Thorsten, Hrishikesh Chakraborty, Linda L Wright and 2 more

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Waldemar A CarloUniversity of Alabama, Birmingham, AL, USA. wcarlo@peds.uab.edu
Shivaprasad S Goudar
Omrana Pasha
Elwyn Chomba
Elizabeth M McClure
Fred J Biasini
Jan L Wallander
Vanessa Thorsten
Hrishikesh Chakraborty
Linda L Wright
Brain Research to Ameliorate Impaired Neurodevelopment-Home-based Intervention Trial Committee
National Institute of Child Health and Human Development Global Network for Women’s and Children’s Health Research

Funding

Zika in Pregnancy Supplemental Funding requestU01HD040636 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MCCLURE, ELIZABETH M · 2001 to 2017
$37.5M
Global Network for Women's and Children's Health Research Data Coordinating CenterU24HD092094 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Elizabeth M McClure · 2017 to 2026
$17.8M
UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
UMKC-JNMC Global Network for Women's and Children's Health Research UnitU01HD042372 · NICHD · UNIVERSITY OF MISSOURI KANSAS CITY · PI DERMAN, RICHARD J · 2001 to 2012
$6.9M
Neonatal Resuscitation in Developing CountriesU01HD043464 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 2003 to 2012
$6.6M
BRAIN Planning Grant for the Developing WorldR21TW006703 · FIC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO, WALDEMAR A. · 2003 to 2005
$311k
FIC NIH HHS R21 TW006703FIC NIH HHS TW006703NICHD NIH HHS HD40607NICHD NIH HHS HD40636NICHD NIH HHS HD42372NICHD NIH HHS HD43464NICHD NIH HHS U01 HD040607NICHD NIH HHS U01 HD040636NICHD NIH HHS U01 HD042372NICHD NIH HHS U01 HD043464NICHD NIH HHS U24 HD092094
6 · The paper itself

Abstract

objectiveTo determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment. STUDY

designInfants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported.

resultsThe study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index <85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P = .22) and in other neurodevelopmental outcomes.

conclusionsMost infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments.

Indexed as

Child DevelopmentDeveloping CountriesDevelopmental DisabilitiesFemaleHumansIncidenceIndiaInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightLearning DisabilitiesMaleMental DisordersNeuropsychological TestsPakistan

Identifiers

PMID22099522
PMCPMC3309169

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.