ArticleNeuron2011
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β.Science China. Life sciences · 2026Article
- Genetic interaction ofFrontiers in neuroscience · 2026Article
- Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome.Communications biology · 2025Article
- A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats.Molecular psychiatry · 2023Article
- Behavioral analysis through the lifespan ofiScience · 2023Article
- How mechanisms of stem cell polarity shape the human cerebral cortex.Nature reviews. Neuroscience · 2022Review
- A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.Cell discovery · 2022Article
- Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia.Scientific reports · 2022Article
- Genetic and Epigenetic Regulation of Brain Organoids.Frontiers in cell and developmental biology · 2022Review
- Modeling neurological disorders using brain organoids.Seminars in cell & developmental biology · 2021Review
- β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.The EMBO journal · 2020Article
- The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity.Molecular brain · 2020Article
- Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.Cell stem cell · 2020Article
- A Novel Schizophrenia Diagnostic Model Based on Statistically Significant Changes in Gene Methylation in Specific Brain Regions.BioMed research international · 2020Article
- Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice.Cell death & disease · 2019Article
- Review
- Disrupted-in-schizophrenia 1 functional polymorphisms and DGenes, brain, and behavior · 2019Article
- The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood.Schizophrenia research · 2019Article
- Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model.Journal of developmental biology · 2018Review
- Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.Translational psychiatry · 2018Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric disorders and has many roles during brain development. Common DISC1 polymorphisms (variants) are associated with neuropsychiatric phenotypes including altered cognition, brain structure, and function; however, it is unknown how this occurs. Here, we demonstrate using mouse, zebrafish, and human model systems that DISC1 variants are loss of function in Wnt/GSK3β signaling and disrupt brain development. The DISC1 variants A83V, R264Q, and L607F, but not S704C, do not activate Wnt signaling compared with wild-type DISC1 resulting in decreased neural progenitor proliferation. In zebrafish, R264Q and L607F could not rescue DISC1 knockdown-mediated aberrant brain development. Furthermore, human lymphoblast cell lines endogenously expressing R264Q displayed impaired Wnt signaling. Interestingly, S704C inhibited the migration of neurons in the developing neocortex. Our data demonstrate DISC1 variants impair Wnt signaling and brain development and elucidate a possible mechanism for their role in neuropsychiatric phenotypes.
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