ArticleCritical care (London, England)2011
Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Cryptic and Overt Acute Kidney Injury Share Biomarker Characteristics in Pediatric Acute Respiratory Distress Syndrome.Critical care explorations · 2026Observational
- Multi-omic and computational approaches for biomarker discovery and clinical translation in pediatric sepsis.Frontiers in pharmacology · 2026Review
- Serum renin and prorenin concentrations predict severe persistent acute kidney injury and mortality in pediatric septic shock.Pediatric nephrology (Berlin, Germany) · 2023Observational
- The complement system in pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2023Review
- Multimerin-1 and cancer: a review.Bioscience reports · 2022Review
- Multi-Omics Techniques Make it Possible to Analyze Sepsis-Associated Acute Kidney Injury Comprehensively.Frontiers in immunology · 2022Review
- Clinical phenotypes of acute kidney injury are associated with unique outcomes in critically ill septic children.Pediatric research · 2021Observational
- Recalibration of the Renal Angina Index for Pediatric Septic Shock.Kidney international reports · 2021Article
- Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury.Hereditas · 2021Article
- Use of the Selective Cytopheretic Device in Critically Ill Children.Kidney international reports · 2021Article
- Sepsis-Pathophysiology and Therapeutic Concepts.Frontiers in medicine · 2021Review
- A Precision Medicine Approach to Biomarker Utilization in Pediatric Sepsis-Associated Acute Kidney Injury.Frontiers in pediatrics · 2021Review
- Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission.Frontiers in immunology · 2021Article
- Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery.Critical care (London, England) · 2020Article
- Identifying the Patient at Risk for Acute Kidney Injury: Pediatric Sepsis Biomarker Risk Model Study.American journal of respiratory and critical care medicine · 2020Article
- PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock.American journal of respiratory and critical care medicine · 2020Observational
- Juvenile OLFM4-null mice are protected from sepsis.American journal of physiology. Renal physiology · 2020Article
- Prognostic and predictive enrichment in sepsis.Nature reviews. Nephrology · 2020Review
- PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis.Physiological reports · 2019Article
- Sepsis Biomarkers.Journal of pediatric intensive care · 2019Review
Corrections and comments
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Authors and funding
16 authors at 13 institutions in 2 countries.
Funding
Abstract
introductionSeptic-shock-associated acute kidney injury (SSAKI) carries high morbidity in the pediatric population. Effective treatment strategies are lacking, in part due to poor detection and prediction. There is a need to identify novel candidate biomarkers of SSAKI. The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI.
methodsA retrospective cohort study compared microarray data representing the first 24 hours of admission for 179 children with septic shock with those of 53 age-matched normal controls. SSAKI was defined as a >200% increase of baseline serum creatinine, persistent to 7 days after admission.
resultsPatients with SSAKI (n = 31) and patients without SSAKI (n = 148) were clinically similar, but SSAKI carried a higher mortality (45% vs. 10%). Twenty-one unique gene probes were upregulated in SSAKI patients versus patients without SSAKI. Using leave-one-out cross-validation and class prediction modeling, these probes predicted SSAKI with a sensitivity of 98% (95% confidence interval (CI) = 81 to 100) and a specificity of 80% (95% CI = 72 to 86). Serum protein levels of two specific genes showed high sensitivity for predicting SSAKI: matrix metalloproteinase-8 (89%, 95% CI = 64 to 98) and elastase-2 (83%, 95% CI = 58 to 96). Both biomarkers carried a negative predictive value of 95%. When applied to a validation cohort, although both biomarkers carried low specificity (matrix metalloproteinase-8: 41%, 95% CI = 28 to 50; and elastase-2: 49%, 95% CI = 36 to 62), they carried high sensitivity (100%, 95% CI = 68 to 100 for both).
conclusionsGene probes upregulated in critically ill pediatric patients with septic shock may allow for the identification of novel candidate serum biomarkers for SSAKI prediction.
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