ArticleJournal of the mechanical behavior of biomedical materials2011
Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus.
Article in Journal of the mechanical behavior of biomedical materials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide.JOR spine · 2024Article
- Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix.Acta biomaterialia · 2021Article
- Interlamellar matrix governs human annulus fibrosus multiaxial behavior.Scientific reports · 2020Article
- Theory of MRI contrast in the annulus fibrosus of the intervertebral disc.Magma (New York, N.Y.) · 2016Article
- Correlation between biomechanical properties of the annulus fibrosus and magnetic resonance imaging (MRI) findings.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Article
- Derivation of inter-lamellar behaviour of the intervertebral disc annulus.Journal of the mechanical behavior of biomedical materials · 2015Article
- Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent.Journal of biomechanics · 2014Article
- Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering.Journal of biomechanics · 2014Article
- Mechanical properties of the extra-fibrillar matrix of human annulus fibrosus are location and age dependent.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading.Annals of biomedical engineering · 2012Article
- Human annulus fibrosus material properties from biaxial testing and constitutive modeling are altered with degeneration.Biomechanics and modeling in mechanobiology · 2012Article
- Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds.Journal of the mechanical behavior of biomedical materials · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The intervertebral disc experiences combinations of compression, torsion, and bending that subject the disc substructures, particularly the annulus fibrosus (AF), to multidirectional loads and deformations. Combined tensile and shear loading is a particularly important loading paradigm, as compressive loads place the AF in circumferential hoop tension, and spine torsion or bending induces AF shear. Yet the anisotropy of AF mechanical properties in shear, as well as important structure-function mechanisms governing this response, are not well-understood. The objective of this study, therefore, was to investigate the effects of tissue orientation and enzymatic degradation of glycosaminoglycan (GAG) and elastin on AF shear mechanical properties. Significant anisotropy was found: the circumferential shear modulus, Gθz, was an order of magnitude greater than the radial shear modulus, Grθ. In the circumferential direction, prestrain significantly increased the shear modulus, suggesting an important role for collagen fiber stretch in shear properties for this orientation. While not significant and highly variable, ChABC treatment to remove GAG increased the circumferential shear modulus compared to PBS control (p=0.15). Together with the established literature for tensile loading of fiber-reinforced GAG-rich tissues, the trends for changes in shear modulus with ChABC treatment reflect complex, structure-function relationships between GAG and collagen that potentially occur over several hierarchical scales. Elastase digestion did not significantly affect shear modulus with respect to PBS control; further contributing to the notion that circumferential shear modulus is dominated by collagen fiber stretch. The results of this study highlight the complexity of the structure-function relationships that govern the mechanical response of the AF in radial and circumferential shear, and provide new and more accurate data for the validation of material models and tissue-engineered disc replacements.
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Registered trials
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