ArticleCardiovascular diabetology2011
Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes.
Article in Cardiovascular diabetology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial.Acta diabetologica · 2016Trial
- Trial
- Haptoglobin genotype is a risk factor for coronary artery disease in prediabetes: A case-control study.American journal of preventive cardiology · 2024Article
- Cardiovascular Disease in Adults with Type 1 Diabetes: Looking Beyond Glycemic Control.Current cardiology reports · 2022Review
- Epidemiological Research Advances in Vascular Calcification in Diabetes.Journal of diabetes research · 2021Review
- Haptoglobin as a Biomarker.Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry · 2021Article
- Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.Molecular genetics & genomic medicine · 2020Article
- The early detection of atherosclerosis in type 1 diabetes: why, how and what to do about it.Cardiovascular endocrinology & metabolism · 2019Review
- Atherosclerosis and Microvascular Complications: Results From the Canadian Study of Longevity in Type 1 Diabetes.Diabetes care · 2018Article
- Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients.Cardiovascular diabetology · 2018Article
- Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Oncotarget · 2017Article
- The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes.Journal of diabetes and its complications · 2016Article
- Pharmacogenomic interaction between the Haptoglobin genotype and vitamin E on atherosclerotic plaque progression and stability.Atherosclerosis · 2015Article
- Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association.Diabetes care · 2014Review
- Cardiovascular, diabetes, and cancer strips: evidences, mechanisms, and classifications.Journal of thoracic disease · 2014Review
- Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes.Diabetes & vascular disease research · 2014Article
- Patient selection and vitamin E treatment in diabetes mellitus.Expert review of cardiovascular therapy · 2013Review
- Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study.Cardiovascular diabetology · 2013Article
- A review of haptoglobin typing methods for disease association study and preventing anaphylactic transfusion reaction.BioMed research international · 2013Review
- Haptoglobin genotype and its role in diabetic cardiovascular disease.Journal of cardiovascular translational research · 2012Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCoronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis.
methodsCAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis.
resultsThe Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes.
conclusionsHp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.
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