ArticleBiophysical journal2011
Trafficking coordinate description of intracellular transport control of signaling networks.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Postsynaptic Stability and Variability Described by a Stochastic Model of Endosomal Trafficking.Frontiers in cellular neuroscience · 2019Article
- Insights into Signaling and the Functional Complexity of Biological Membranes.The Journal of membrane biology · 2017Article
- The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.PLoS computational biology · 2014Article
- Literature-based automated reconstruction, expansion, and refinement of the TGF-β superfamily ligand-receptor network.The Journal of membrane biology · 2014Article
- In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes.Journal of theoretical biology · 2013Article
- Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.Journal of the Royal Society, Interface · 2013Article
- Coupled reversible and irreversible bistable switches underlying TGFβ-induced epithelial to mesenchymal transition.Biophysical journal · 2013Article
- Article
- Dynamics of TGF-β/Smad signaling.FEBS letters · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cellular networks rely on the regulated transport of their components to transduce extracellular information into precise intracellular signals. The dynamics of these networks is typically described in terms of compartmentalized chemical reactions. There are many important situations, however, in which the properties of the compartments change continuously in a way that cannot naturally be described by chemical reactions. Here, we develop an approach based on transport along a trafficking coordinate to precisely describe these processes and we apply it explicitly to the TGF-β signal transduction network, which plays a fundamental role in many diseases and cellular processes. The results of this newly introduced approach accurately capture the distinct TGF-β signaling dynamics of cells with and without cancerous backgrounds and provide an avenue to predict the effects of chemical perturbations in a way that closely recapitulates the observed cellular behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.