ArticleAntioxidants & redox signaling2012
Oxygen regulates tissue nitrite metabolism.
Article in Antioxidants & redox signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Nitric oxide treatments as adjuncts to reperfusion in acute myocardial infarction: a systematic review of experimental and clinical studies.Basic research in cardiology · 2016Pooled it
- Pharmacokinetics, pharmacodynamics, safety, and tolerability of nebulized sodium nitrite (AIR001) following repeat-dose inhalation in healthy subjects.Clinical pharmacokinetics · 2015Trial
- Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides.Nitric oxide : biology and chemistry · 2022Article
- Risk assessment of nitrate and nitrite in feed.EFSA journal. European Food Safety Authority · 2020Article
- Myoglobin promotes nitrite-dependent mitochondrial S-nitrosation to mediate cytoprotection after hypoxia/reoxygenation.Nitric oxide : biology and chemistry · 2020Article
- Bioenergetic Differences in the Airway Epithelium of LeanAntioxidants & redox signaling · 2019Article
- The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice.Nitric oxide : biology and chemistry · 2018Article
- Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.Redox biology · 2018Article
- Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model.Microvascular research · 2017Article
- Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism.Toxicology and applied pharmacology · 2015Article
- Article
- Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.Free radical biology & medicine · 2015Article
- Extracellular hemoglobin: the case of a friend turned foe.Frontiers in physiology · 2015Review
- Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion.Cardiovascular research · 2014Article
- Crosstalk between nitrite, myoglobin and reactive oxygen species to regulate vasodilation under hypoxia.PloS one · 2014Article
- Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway.British journal of clinical pharmacology · 2013Article
- Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic.PloS one · 2013Article
- Heme/copper assembly mediated nitrite and nitric oxide interconversion.Journal of the American Chemical Society · 2012Article
- S-nitrosation: current concepts and new developments.Antioxidants & redox signaling · 2012Article
- Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase.Free radical biology & medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
aimsOnce dismissed as an inert byproduct of nitric oxide (NO) auto-oxidation, nitrite (NO(2)(-)) is now accepted as an endocrine reservoir of NO that elicits biological responses in major organs. While it is known that tissue nitrite is derived from NO oxidation and the diet, little is known about how nitrite is metabolized by tissue, particularly at intermediate oxygen tensions. We investigated the rates and mechanisms of tissue nitrite metabolism over a range of oxygen concentrations.
resultsWe show that the rate of nitrite consumption differs in each organ. Further, oxygen regulates the rate and products of nitrite metabolism. In anoxia, nitrite is reduced to NO, with significant formation of iron-nitrosyl proteins and S-nitrosothiols. This hypoxic nitrite metabolism is mediated by different nitrite reductases in each tissue. In contrast, low concentrations (∼3.5 μM) of oxygen increase the rate of nitrite consumption by shifting nitrite metabolism to oxidative pathways, yielding nitrate. While cytochrome P(450) and myoglobin contribute in the liver and heart, respectively, mitochondrial cytochrome c oxidase plays a significant role in nitrite oxidation, which is inhibited by cyanide. Using cyanide to prevent artifactual nitrite decay, we measure metabolism of oral and intraperitoneally administered nitrite in mice. INNOVATION: These data provide insight into the fate of nitrite in tissue, the enzymes involved in nitrite metabolism, and the role of oxygen in regulating these processes.
conclusionWe demonstrate that even at low concentrations, oxygen is a potent regulator of the rate and products of tissue nitrite metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.