Evidence map›Paper›PMID 22098274›Full record

ArticleAnalytical chemistry2012

Optical sensing by transforming chromophoric silver clusters in DNA nanoreactors.

Jeffrey T Petty, Sandra P Story, Selina Juarez, Samuel S Votto, Austin G Herbst, Natalya N Degtyareva, Bidisha Sengupta

Abstract read
In one paragraph

Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Interrupted DNA and Slow Silver Cluster Luminescence.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. DNA-Directed Fluorescence Switching of Silver Clusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015
    Article
  15. Article
  16. Article
  17. A silver cluster-DNA equilibrium.Analytical chemistry · 2013
    Article
  18. DNA-Templated Molecular Silver Fluorophores.The journal of physical chemistry letters · 2013
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeffrey T PettyDepartment of Chemistry, Furman University, Greenville, South Carolina 29163, USA. jeff.petty@furman.edu
Sandra P Story
Selina Juarez
Samuel S Votto
Austin G Herbst
Natalya N Degtyareva
Bidisha Sengupta

Funding

Supplement for South Carolina BRIN - 1P20 RR16461P20RR016461 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI DEAVOR, JAMES · 2001 to 2011
$32.3M
The Effect of Water on Sequence Specific DNA RecognitionR15GM071370 · NIGMS · FURMAN UNIVERSITY · PI PETTY, JEFFREY T · 2004 to 2004
$215k
DNA-Silver Cluster Complexes for Fluorescent DiagnosticsR15GM084442 · NIGMS · FURMAN UNIVERSITY · PI PETTY, JEFFREY THOMAS · 2008 to 2008
$215k
Howard Hughes Medical InstituteNCRR NIH HHS P20 RR016461NIGMS NIH HHS R15 GM071370NIGMS NIH HHS R15GM071370NIGMS NIH HHS R15 GM084442
6 · The paper itself

Abstract

Bifunctional DNA oligonucleotides serve as templates for chromophoric silver clusters and as recognition sites for target DNA strands, and communication between these two components is the basis of an oligonucleotide sensor. Few-atom silver clusters exhibit distinct electronic spectra spanning the visible and near-infrared region, and they are selectively synthesized by varying the base sequence of the DNA template. In these studies, a 16-base cluster template is adjoined with a 12-base sequence complementary to the target analyte, and hybridization induces structural changes in the composite sensor that direct the conversion between two spectrally and stoichiometrically distinct clusters. Without its complement, the sensor strand selectively harbors ~7 Ag atoms that absorb at 400 nm and fold the DNA host. Upon association of the target with its recognition site, the sensor strand opens to expose the cluster template that has the binding site for ~11 Ag atoms, and absorption at 720 nm with relatively strong emission develops in lieu of the violet absorption. Variations in the length and composition of the recognition site and the cluster template indicate that these types of dual-component sensors provide a general platform for near-infrared-based detection of oligonucleotides in challenging biological environments.

Indexed as

NanotechnologyOptics and PhotonicsDNASilverDNASilver

Identifiers

PMID22098274
PMCPMC4532300

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.