Trial reportJournal of cognitive neuroscience2012
Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward.
Trial report in Journal of cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Decreased Central Nervous System Grey Matter Volume (GMV) in Smokers Affects Cognitive Abilities: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2017Pooled it
- Impaired arbitration between reward-related decision-making strategies in Alcohol Users compared to Alcohol Non-Users: a computational modeling study.NPP - digital psychiatry and neuroscience · 2025Article
- The pornography use and its addiction among emerging adults in Malaysia: Perceived realism as a mediator.PloS one · 2022Article
- Relationships between Personality Traits and Brain Gray Matter Are Different in Risky and Non-risky Drivers.Behavioural neurology · 2022Article
- Differential Impact of Social and Monetary Reward on Procedural Learning and Consolidation in Aging and Its Structural Correlates.Frontiers in aging neuroscience · 2019Article
- Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC.Addiction biology · 2019Article
- Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder.Scientific reports · 2017Article
- Neuroimaging the Effectiveness of Substance Use Disorder Treatments.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- The influence of monetary incentives on context processing in younger and older adults: an event-related potential study.Cognitive, affective & behavioral neuroscience · 2015Article
- Multimodal evidence of regional midcingulate gray matter volume underlying conflict monitoring.NeuroImage. Clinical · 2014Article
- Prenatal cocaine exposure and gray matter volume in adolescent boys and girls: relationship to substance use initiation.Biological psychiatry · 2013Article
- Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence.Biological psychiatry · 2013Article
- Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen.Psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The P300 is a known ERP component assessing stimulus value, including the value of a monetary reward. In parallel, the incentive value of reinforcers relies on the PFC, a major cortical projection region of the mesocortical reward pathway. Here we show a significant positive correlation between P300 response to money (vs. no money) with PFC gray matter volume in the OFC, ACC, and dorsolateral and ventrolateral PFC in healthy control participants. In contrast, individuals with cocaine use disorders showed compromises in both P300 sensitivity to money and PFC gray matter volume in the ventrolateral PFC and OFC and their interdependence. These results document for the first time the importance of gray matter structural integrity of subregions of PFC to the reward-modulated P300 response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.