Trial reportThe European journal of neuroscience2011
Do brain responses to emotional images and cigarette cues differ? An fMRI study in smokers.
Trial report in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging craving: urge intensity matters.Addiction (Abingdon, England) · 2015Pooled it
- Benefits of varenicline vs. bupropion for smoking cessation: a Bayesian analysis of the interaction of reward sensitivity and treatment.Psychopharmacology · 2017Trial
- Brain responses to erotic and other emotional stimuli in breast cancer survivors with and without distress about low sexual desire: a preliminary fMRI study.Brain imaging and behavior · 2013Trial
- An Exploratory Study of an fMRI Reward-Learning Paradigm in Developing Adolescents.Children (Basel, Switzerland) · 2026Article
- Dissociating moral identity from neural markers of the late positive potential in emotional attention to smoking and non-smoking stimuli.AIMS neuroscience · 2026Article
- Electrophysiological normative responses to emotional, neutral, and cigarette-related images.Psychophysiology · 2023Article
- Explicit and Implicit Devaluation Effects of Food-Specific Response Inhibition Training.Journal of cognition · 2023Article
- Repetitive transcranial magnetic stimulation for smoking cessation: a pivotal multicenter double-blind randomized controlled trial.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Sustained brain response to repeated drug cues is associated with poor drug-use outcomes.Addiction biology · 2021Article
- The impact of nicotine dose and instructed dose on smokers' implicit attitudes to smoking cues: An ERP study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Neural correlates of tobacco cue reactivity predict duration to lapse and continuous abstinence in smoking cessation treatment.Addiction biology · 2018Article
- Beyond Cue Reactivity: Non-Drug-Related Motivationally Relevant Stimuli Are Necessary to Understand Reactivity to Drug-Related Cues.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Review
- Smokers exhibit biased neural processing of smoking and affective images.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016Article
- Conditioned cortical reactivity to cues predicting cigarette-related or pleasant images.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Article
- Belief about Nicotine Modulates Subjective Craving and Insula Activity in Deprived Smokers.Frontiers in psychiatry · 2016Article
- Cigarette Cravings, Impulsivity, and the Brain.Frontiers in psychiatry · 2015Review
- Clarifying the neural basis for incentive salience of tobacco cues in smokers.Psychiatry research · 2014Article
- Prequit fMRI responses to pleasant cues and cigarette-related cues predict smoking cessation outcome.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Article
- Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals.Psychopharmacology · 2014Article
- Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls.Drug and alcohol dependence · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Chronic smoking is thought to cause changes in brain reward systems that result in overvaluation of cigarette-related stimuli and undervaluation of natural rewards. We tested the hypotheses that, in smokers, brain circuits involved in emotional processing: (i) would be more active during exposure to cigarette-related than neutral pictures; and (ii) would be less active to pleasant compared with cigarette-related pictures, suggesting a devaluation of intrinsically pleasant stimuli. We obtained whole-brain blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging data from 35 smokers during the presentation of pleasant (erotica and romance), unpleasant (mutilations and sad), neutral, and cigarette-related pictures. Whole-brain analyses showed significantly larger BOLD responses during presentation of cigarette-related pictures relative to neutral ones within the secondary visual areas, the cingulate gyrus, the frontal gyrus, the dorsal striatum, and the left insula. BOLD responses to erotic pictures exceeded responses to cigarette-related pictures in all clusters except the insula. Within the left insula we observed larger BOLD responses to cigarette-related pictures than to all other picture categories. By including intrinsically pleasant and unpleasant pictures in addition to neutral ones, we were able to conclude that the presentation of cigarette-related pictures activates brain areas supporting emotional processes, but we did not find evidence of overall reduced activation of the brain reward systems in the presence of intrinsically pleasant stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.