ArticlePloS one2011
Molecular basis of virulence in Staphylococcus aureus mastitis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 88 citations in OpenAlex.
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- Gut microbial metabolite indole-3-propionic acid inhibits inflammation and restores blood-milk barrier inFrontiers in microbiology · 2025Article
- Zoonotic transmission of asymptomatic carriageMicrobial genomics · 2024Article
- Phylogenetic analysis ofOpen veterinary journal · 2024Article
- A Stochastic Frontier Approach to Study the Relationship between the Hygienic Quality of Bulk Tank Sheep Milk and Technical Efficiency of the Coagulation Process.Foods (Basel, Switzerland) · 2024Article
- On-farm epidemiology and phylogenetic evaluation of methicillin and beta-lactam-resistantIranian journal of veterinary research · 2024Article
- Occurrence of Virulence Genes among Methicillin-ResistantACS omega · 2023Article
- Development of a Nomogram to Estimate the 60-Day Probability of Death or Culling Due to Severe Clinical Mastitis in Dairy Cows at First Veterinary Clinical Evaluation.Veterinary sciences · 2023Article
- Comparative secretome analysis ofVirulence · 2022Article
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- Proteomic Profiles of Staphylococcus aureus Strains Associated with Subclinical Bovine Mastitis.Current microbiology · 2022Article
- The Genetic Relatedness and Antimicrobial Resistance Patterns of Mastitis-CausingVeterinary sciences · 2021Article
- Prevalence, antibiotic resistance, virulence and genetic diversity of Staphylococcus aureus isolated from bulk tank milk samples of U.S. dairy herds.BMC genomics · 2021Article
- Whole-Genome Epidemiology and Characterization of Methicillin-SusceptibleFrontiers in microbiology · 2021Article
- Article
- Whole-Genome Comparisons ofApplied and environmental microbiology · 2020Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundS. aureus is one of the main pathogens involved in ruminant mastitis worldwide. The severity of staphylococcal infection is highly variable, ranging from subclinical to gangrenous mastitis. This work represents an in-depth characterization of S. aureus mastitis isolates to identify bacterial factors involved in severity of mastitis infection. METHODOLOGY/PRINCIPAL
findingsWe employed genomic, transcriptomic and proteomic approaches to comprehensively compare two clonally related S. aureus strains that reproducibly induce severe (strain O11) and milder (strain O46) mastitis in ewes. Variation in the content of mobile genetic elements, iron acquisition and metabolism, transcriptional regulation and exoprotein production was observed. In particular, O11 produced relatively high levels of exoproteins, including toxins and proteases known to be important in virulence. A characteristic we observed in other S. aureus strains isolated from clinical mastitis cases. CONCLUSIONS/SIGNIFICANCE: Our data are consistent with a dose-dependant role of some staphylococcal factors in the hypervirulence of strains isolated from severe mastitis. Mobile genetic elements, transcriptional regulators, exoproteins and iron acquisition pathways constitute good targets for further research to define the underlying mechanisms of mastitis severity.
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