ArticleAnatomical record (Hoboken, N.J. : 2007)2012
The giant danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration.
Article in Anatomical record (Hoboken, N.J. : 2007), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish.Nature communications · 2026Article
- The goldfish Carassius auratus: an emerging animal model for comparative cardiac research.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Review
- Endocrine Influence on Cardiac Metabolism in Development and Regeneration.Endocrinology · 2021Review
- Nucleated red blood cells participate in myocardial regeneration in the toadExperimental biology and medicine (Maywood, N.J.) · 2021Article
- Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates.Advanced genetics (Hoboken, N.J.) · 2021Article
- Cardiac regenerative capacity: an evolutionary afterthought?Cellular and molecular life sciences : CMLS · 2021Review
- Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Review
- Vertebrate cardiac regeneration: evolutionary and developmental perspectives.Cell regeneration (London, England) · 2021Review
- Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration.Journal of cardiovascular development and disease · 2021Review
- Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart.Journal of cardiovascular development and disease · 2020Article
- Zebrafish heart regeneration: Factors that stimulate cardiomyocyte proliferation.Seminars in cell & developmental biology · 2020Review
- Transcriptional Programs and Regeneration Enhancers Underlying Heart Regeneration.Journal of cardiovascular development and disease · 2018Review
- The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).Journal of the American College of Cardiology · 2018Review
- Heart Development, Coronary Vascularization and Ventricular Maturation in a Giant Danio (Journal of developmental biology · 2018Article
- Zebrafish heart regeneration: 15 years of discoveries.Regeneration (Oxford, England) · 2017Review
- Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio ( Devario aequipinnatus) and Zebrafish ( Danio rerio) Hearts.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue?Seminars in cell & developmental biology · 2016Review
- Building and re-building the heart by cardiomyocyte proliferation.Development (Cambridge, England) · 2016Review
- Evolution, comparative biology and ontogeny of vertebrate heart regeneration.NPJ Regenerative medicine · 2016Review
- Beyond the Mammalian Heart: Fish and Amphibians as a Model for Cardiac Repair and Regeneration.Journal of developmental biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The paucity of mammalian adult cardiac myocytes (CM) proliferation following myocardial infarction (MI) and the remodeling of the necrotic tissue that ensues, result in non-regenerative repair. In contrast, zebrafish (ZF) can regenerate after an apical resection or cryoinjury of the heart. There is considerable interest in models where regeneration proceeds in the presence of necrotic tissue. We have developed and characterized a cautery injury model in the giant danio (GD), a species closely related to ZF, where necrotic tissue remains part of the ventricle, yet regeneration occurs. By light and transmission electron microscopy (TEM), we have documented four temporally overlapping processes: (1) a robust inflammatory response analogous to that observed in MI, (2) concomitant proliferation of epicardial cells leading to wound closure, (3) resorption of necrotic tissue and its replacement by granulation tissue, and (4) regeneration of the myocardial tissue driven by 5-EDU and [(3) H]thymidine incorporating CMs. In conclusion, our data suggest that the GD possesses robust repair mechanisms in the ventricle and can serve as an important model of cardiac inflammation, remodeling and regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.