ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Micrometer-sized titanium particles can induce potent Th2-type responses through TLR4-independent pathways.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Soft Tissue Response to Titanium Abutments with Different Surface Treatment: Preliminary Histologic Report of a Randomized Controlled Trial.BioMed research international · 2016Trial
- Soft tissue cell adhesion to titanium abutments after different cleaning procedures: preliminary results of a randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2014Trial
- Vacuum Plasma Treatment Device for Enhancing Fibroblast Activity on Machined and Rough Titanium Surfaces.Dentistry journal · 2024Article
- Influence of exposure of customized dental implant abutments to different cleaning procedures: an in vitro study using AI-assisted SEM/EDS analysis.International journal of implant dentistry · 2023Article
- Immune response differences in degradable and non-degradable alloy implants.Bioactive materials · 2023Review
- Biocompatibility, Surface Morphology, and Bacterial Load of Dental Implant Abutments following Decontamination Protocols: An In-Vitro Study.Materials (Basel, Switzerland) · 2023Article
- Microbiological cleaning and disinfection efficacy of a three-stage ultrasonic processing protocol for CAD-CAM implant abutments.The journal of advanced prosthodontics · 2022Article
- Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering ACell reports · 2022Article
- The efficacy of convenient cleaning methods applicable for customized abutments: an in vitro study.BMC oral health · 2021Article
- Early Events Triggering the Initiation of a Type 2 Immune Response.Trends in immunology · 2021Review
- Inhalant Mammal-Derived Lipocalin Allergens and the Innate Immunity.Frontiers in allergy · 2021Review
- Heterogeneity in the initiation, development and function of type 2 immunity.Nature reviews. Immunology · 2020Review
- Qualitative and Semi-Quantitative Assessment of Processing-Related Surface Contamination of One- and Two-Piece CAD/CAM Abutments before and after Ultrasonic Cleaning.Materials (Basel, Switzerland) · 2020Article
- Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models.Frontiers in immunology · 2020Review
- Cytokine Profile in Patients with Aseptic Loosening of Total Hip Replacements and Its Relation to Metal Release and Metal Allergy.Journal of clinical medicine · 2019Article
- Induction of sterile type 2 inflammation.Nature materials · 2019Article
- Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.Nature materials · 2019Article
- Article
- Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages.Scientific reports · 2016Article
- The effects of icariine concentration on osteoclasts bone resorption induced by titanium particles in vitro.Regenerative biomaterials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Wear debris in joint replacements has been suggested as a cause of associated tissue-damaging inflammation. In this study, we examined whether solid titanium microparticles (mTi) of sufficient size to accumulate as wear debris could stimulate innate or adaptive immunity in vivo. mTi, administered in conjunction with OVA, promoted total and Ag-specific elevations in serum IgE and IgG1. Analysis of transferred transgenic OVA-specific naive T cells further showed that mTi acted as an adjuvant to drive Ag-specific Th2 cell differentiation in vivo. Assessment of the innate response indicated that mTi induced rapid recruitment and differentiation of alternatively activated macrophages in vivo, through IL-4- and TLR4-independent pathways. These studies suggest that solid microparticles alone can act as adjuvants to induce potent innate and adaptive Th2-type immune responses and further suggest that wear debris in joint replacements may have Th2-type inflammatory properties.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.