Evidence map›Paper›PMID 22095569›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012

Ribosomal RNA evidence of ocular Chlamydia trachomatis infection following 3 annual mass azithromycin distributions in communities with highly prevalent trachoma.

Jeremy D Keenan, Berhan Ayele, Teshome Gebre, Jeanne Moncada, Nicole E Stoller, Zhaoxia Zhou, Travis C Porco, Charles E McCulloch, Bruce D Gaynor, Paul M Emerson and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Antibiotics for trachoma.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Trachoma: an update on prevention, diagnosis, and treatment.Current opinion in ophthalmology · 2012
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jeremy D KeenanFI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, CA 94143-0412, USA. jeremy.keenan@ucsf.edu
Berhan Ayele
Teshome Gebre
Jeanne Moncada
Nicole E Stoller
Zhaoxia Zhou
Travis C Porco
Charles E McCulloch
Bruce D Gaynor
Paul M Emerson
Julius Schachter
Thomas M Lietman

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
TANA IIU10EY016214 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIETMAN, THOMAS M · 2004 to 2013
$4.4M
Optimal trachoma control after mass antibiotic distributionsK23EY019071 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2008 to 2012
$982k
NCRR NIH HHS KL2 RR024130NEI NIH HHS K23 EY019071NEI NIH HHS K23EY019071NEI NIH HHS U10 EY016214
6 · The paper itself

Abstract

Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7).

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisAzithromycinChildChild, PreschoolChlamydia trachomatisEthiopiaFemaleHumansInfantMalePrevalencePreventive Health ServicesRNA, BacterialRNA, RibosomalStatistics, NonparametricAnti-Bacterial AgentsAzithromycinRNA, BacterialRNA, Ribosomal

Identifiers

PMID22095569
PMCPMC3245728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.