ArticleAmerican journal of respiratory and critical care medicine2012
Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.
- Corticosteroid plus βRespiratory research · 2017Pooled it
- Trial
- Serum periostin is associated with type 2 immunity in severe asthma.The Journal of allergy and clinical immunology · 2016Trial
- Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies.Thorax · 2015Trial
- Asthma Is More Severe in Older Adults.PloS one · 2015Trial
- Fixed airflow obstruction in asthma: a descriptive study of patient profiles and effect on treatment responses.The Journal of asthma : official journal of the Association for the Care of Asthma · 2014Trial
- Beyond symptoms: uncovering type 2 inflammation and small airway dysfunction in Treatment-Naïve asthma.BMC pulmonary medicine · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Harmonized low-dose computed tomographic protocols for quantitative lung imaging using dose modulation and advanced reconstructions.Medical physics · 2025Article
- Article
- Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.American journal of respiratory and critical care medicine · 2025Article
- Integrative Roles of Pro-Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma.Immunological reviews · 2025Review
- Patient-centred outcomes in severe asthma: fatigue, sleep, physical activity and work.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Sex differences in asthma: omics evidence and future directions.Frontiers in genetics · 2025Review
- A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital.Journal of clinical medicine · 2024Article
- Ciliary Function, Antigen Stasis and Asthma.International journal of molecular sciences · 2024Review
- A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.American journal of respiratory and critical care medicine · 2024Article
- Respiratory symptoms, exacerbations and sleep disturbances are more common among participants with asthma and chronic airflow limitation: an epidemiological study in Estonia, Iceland and Sweden.BMJ open respiratory research · 2024Article
- Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.JCI insight · 2024Observational
- Factors influencing poor response to type 2 targeted therapies in severe asthma: a retrospective cohort study.BMC pulmonary medicine · 2023Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 2 institutions in 2 countries.
Funding
Abstract
The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.