ArticleThe EMBO journal1990
The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 188 citations in OpenAlex.
- ETS1 Function in Leukemia and Lymphoma.Advances in experimental medicine and biology · 2024Review
- ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent.Blood advances · 2022Article
- The Role of Non-coding RNAs in Viral Myocarditis.Frontiers in cellular and infection microbiology · 2020Review
- Article
- RelB-dependent stromal cells promote T-cell leukemogenesis.PloS one · 2008Article
- Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1.Journal of virology · 2007Article
- Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb.Retrovirology · 2007Article
- Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.Molecular and cellular biology · 2005Article
- Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity.Nucleic acids research · 2005Article
- The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression.Nucleic acids research · 2004Article
- Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.The EMBO journal · 2002Article
- GLI-2 modulates retroviral gene expression.Journal of virology · 2001Article
- Activation of human T-cell leukemia virus type 1 tax gene expression in chronically infected T cells.Journal of virology · 1998Article
- HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression.Nucleic acids research · 1997Article
- cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence.Journal of virology · 1997Article
- Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis.Annals of the rheumatic diseases · 1996Article
- ETS1 suppresses tumorigenicity of human colon cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.Journal of virology · 1995Article
- ets-1 in astrocytes: expression and transmitter-evoked phosphorylation.Molecular and cellular biology · 1995Article
- Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase.Journal of virology · 1994Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-ets-1 proto-oncogene and the related c-ets-2 gene encode related nuclear chromatin-associated proteins which bind DNA in vitro. To investigate the possibility that Ets1 and Ets2 are transcriptional activators, we analyzed the ability of these proteins to trans-activate promoter/enhancer sequences in transient co-transfection experiments. A CAT construct driven by the long terminal repeat of the human T cell leukemia virus, HTLV-1 was found to be trans-activated by both Ets1 and Ets2 in NIH3T3 and HeLa cells. The increased levels of CAT activity were paralleled by increased levels of correctly initiated CAT mRNA. Mutant Ets1 proteins unable to accumulate in the nucleus were found to be inactive. An ets-responsive sequence between positions -117 and -160 of the LTR was identified by analyses of a series of 5' deletion mutants of the HTLV-1 LTR and of dimerized versions of specific motifs of the LTR enhancer region. Using a gel shift binding assay, Ets1 was found to bind specifically to an oligonucleotide corresponding to region -117 to -160. This sequence, which also contributes to Tax1 responsiveness of the HTLV-1 LTR, is characterized by the presence of four repeats of a pentanucleotide sequence of the type CC(T/A)CC. Competition experiments show that integrity of repeats 1 and 4 is important for Ets1 binding. These results show that Ets1 and Ets2 are sequence-specific transcriptional activators. In view of the high level expression of Ets1 in lymphoid cells, Ets1 could be part of the transcription complex which mediates the response to Tax1 and the control of HTLV-1 replication. More generally, Ets1 and Ets2 could regulate transcription of cellular genes.
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