ArticleCell death and differentiation2012

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

D M Moujalled et al.PubMed ↗Full text ↗Publisher ↗

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