ArticleGenetics2012
A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling.Science advances · 2022Article
- CK1α protects WAVE from degradation to regulate cell shape and motility in the immune response.Journal of cell science · 2021Article
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- TheJournal of cell science · 2018Article
- Review
- Article
- COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Development (Cambridge, England) · 2017Article
- SlgA, encoded by the homolog of the human schizophrenia-associated geneDisease models & mechanisms · 2017Article
- Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling inProceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- RZZ and Mad1 dynamics in Drosophila mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation.Development (Cambridge, England) · 2015Article
- Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.PLoS genetics · 2015Article
- Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity.Development (Cambridge, England) · 2014Article
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells.Journal of visualized experiments : JoVE · 2013Article
- Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.Journal of cell science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Wnt and Hedgehog signaling pathways are essential for normal development and are misregulated in cancer. The casein kinase family of serine/threonine kinases regulates both pathways at multiple levels. However, it has been difficult to determine whether individual members of this family have distinct functions in vivo, due to their overlapping substrate specificities. In Drosophila melanogaster, photoreceptor differentiation is induced by Hedgehog and inhibited by Wingless, providing a sensitive system in which to identify regulators of each pathway. We used a mosaic genetic screen in the Drosophila eye to identify mutations in genes on the X chromosome required for signal transduction. We recovered mutations affecting the transcriptional regulator CREB binding protein, the small GTPase dynamin, the cytoskeletal regulator Actin-related protein 2, and the protein kinase Casein kinase 1α. Consistent with its reported function in the β-Catenin degradation complex, Casein Kinase 1α mutant cells accumulate β-Catenin and ectopically induce Wingless target genes. In contrast to previous studies based on RNA interference, we could not detect any effect of the same Casein Kinase 1α mutation on Hedgehog signaling. We thus propose that Casein kinase 1α is essential to allow β-Catenin degradation and prevent inappropriate Wingless signaling, but its effects on the Hedgehog pathway are redundant with other Casein kinase 1 family members.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.