ArticleNeuroImage2012
Along-tract statistics allow for enhanced tractography analysis.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
123 citing papers in PubMed, 245 citations in OpenAlex.
- Graph-Based White Matter Tractometry: Methods, Applications, and the Path to Validation.Neuroinformatics · 2026Review
- The degenerome-a novel streamline-wise approach for white matter integrity in neurodegeneration.NPJ Parkinson's disease · 2026Article
- Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.NMR in biomedicine · 2026Article
- Mapping white matter microstructure at term age to motor outcomes at 2 years in very preterm infants: a multicentre cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Motor learning induces myelin-related white matter changes revealed by MRI-based in vivo histology.Communications biology · 2026Article
- Diffusion Tensor Imaging Biomarkers to Predict Neurological Outcomes in Brain Surgery: A Systematic Review.Life (Basel, Switzerland) · 2026Review
- A rapid streamline-based extension of Tractfinder for white matter tract segmentation.Frontiers in neuroimaging · 2026Article
- Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- A software ecosystem for brain tractometry processing, analysis, and insight.PLoS computational biology · 2025Article
- Damage in thalamic projection to perilesional cortex as a prognostic biomarker for experimental post-traumatic epilepsy.Epilepsia · 2025Article
- Structural White Matter Correlates of the Crowding Effect: Insights From a Tractography Study of the Arcuate Fasciculus Post-Hemispherotomy.Human brain mapping · 2025Article
- Significance of the corpus callosum and inferior fronto-occipital fasciculus in recovery after traumatic brain injury.Neuroradiology · 2025Article
- Along-tract white matter abnormalities and their clinical associations in recent-onset and chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Fiber microstructure quantile (FMQ) regression: A novel statistical approach for analyzing white matter bundles from periphery to core.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Leveling up: along-level diffusion tensor imaging in the spinal cord of multiple sclerosis patients.Frontiers in neuroimaging · 2025Article
- Surface-based Analyses of Diffusional Kurtosis Imaging in Amyotrophic Lateral Sclerosis: Relationship with Onset Subtypes.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Temporopolar blurring signifies abnormalities of white matter in mesial temporal lobe epilepsy.Annals of clinical and translational neurology · 2024Article
- Deep multimodal saliency parcellation of cerebellar pathways: Linking microstructure and individual function through explainable multitask learning.Human brain mapping · 2024Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Diffusion imaging tractography is a valuable tool for neuroscience researchers because it allows the generation of individualized virtual dissections of major white matter tracts in the human brain. It facilitates between-subject statistical analyses tailored to the specific anatomy of each participant. There is prominent variation in diffusion imaging metrics (e.g., fractional anisotropy, FA) within tracts, but most tractography studies use a "tract-averaged" approach to analysis by averaging the scalar values from the many streamline vertices in a tract dissection into a single point-spread estimate for each tract. Here we describe a complete workflow needed to conduct an along-tract analysis of white matter streamline tract groups. This consists of 1) A flexible MATLAB toolkit for generating along-tract data based on B-spline resampling and compilation of scalar data at different collections of vertices along the curving tract spines, and 2) Statistical analysis and rich data visualization by leveraging tools available through the R platform for statistical computing. We demonstrate the effectiveness of such an along-tract approach over the tract-averaged approach in an example analysis of 10 major white matter tracts in a single subject. We also show that these techniques easily extend to between-group analyses typically used in neuroscience applications, by conducting an along-tract analysis of differences in FA between 9 individuals with fetal alcohol spectrum disorders (FASDs) and 11 typically-developing controls. This analysis reveals localized differences between FASD and control groups that were not apparent using a tract-averaged method. Finally, to validate our approach and highlight the strength of this extensible software framework, we implement 2 other methods from the literature and leverage the existing workflow tools to conduct a comparison study.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.