ArticleLeukemia2012
Whole-exome sequencing of pediatric acute lymphoblastic leukemia.
Article in Leukemia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Inflammation as a driver of hematological malignancies.Frontiers in oncology · 2024Review
- Uncovering novel mutational signatures byCell genomics · 2022Article
- Article
- The evolution of relapse of adult T cell acute lymphoblastic leukemia.Genome biology · 2020Article
- ETV6/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol.Italian journal of pediatrics · 2018Article
- Outcome and Prognostic Factors forCancer research and treatment · 2017Article
- Whole-Exome Sequencing of ETV6/RUNX1 in Four Childhood Acute Lymphoblastic Leukaemia CasesAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Emerging technologies in paediatric leukaemia.Translational pediatrics · 2015Review
- The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing.Human mutation · 2015Article
- Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias.Blood · 2014Article
- New lung cancer panel for high-throughput targeted resequencing.Genomics & informatics · 2014Article
- NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.Database : the journal of biological databases and curation · 2014Article
- Integrated analysis of recurrent properties of cancer genes to identify novel drivers.Genome biology · 2013Article
- Don't Mess with RUNX1.Molecular syndromology · 2012Article
- Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.Current hematologic malignancy reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute lymphoblastic leukemia (ALL), the most common malignant disorder in childhood, is typically associated with numerical chromosomal aberrations, fusion genes or small focal deletions, thought to represent important pathogenetic events in the development of the leukemia. Mutations, such as single nucleotide changes, have also been reported in childhood ALL, but these have only been studied by sequencing a small number of candidate genes. Herein, we report the first unbiased sequencing of the whole exome of two cases of pediatric ALL carrying the ETV6/RUNX1 (TEL/AML1) fusion gene (the most common genetic subtype) and corresponding normal samples. A total of 14 somatic mutations were identified, including four and seven protein-altering nucleotide substitutions in each ALL. Twelve mutations (86%) occurred in genes previously described to be mutated in other types of cancer, but none was found to be recurrent in an extended series of 29 ETV6/RUNX1-positive ALLs. The number of single nucleotide mutations was similar to the number of copy number alterations as detected by single nucleotide polymorphism arrays. Although the true pathogenetic significance of the mutations must await future functional evaluations, this study provides a first estimate of the mutational burden at the genetic level of t(12;21)-positive childhood ALL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.