ArticleJournal of molecular neuroscience : MN2012
Changes of peroxisome proliferator-activated receptor-γ on crushed rat sciatic nerves and differentiated primary Schwann cells.
Article in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring the potential anti-diabetic peripheral neuropathy mechanisms of Huangqi Guizhi Wuwu Decoction by network pharmacology and molecular docking.Metabolic brain disease · 2024Article
- Genome-wide Analysis of Histone H3 Lysine 27 Trimethylation Profiles in Sciatic Nerve of Chronic Constriction Injury Rats.Neurochemical research · 2023Article
- Characterization of pain-related behaviors and gene expression profiling of peripheral sensory ganglia in a mouse model of acute ankle sprain.Frontiers in behavioral neuroscience · 2023Article
- Article
- PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3.Cell death discovery · 2021Article
- Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries.Biomolecules · 2021Review
- De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.The Journal of cell biology · 2018Article
- PPARγ Agonists Attenuate Trigeminal Neuropathic Pain.The Clinical journal of pain · 2017Article
- Hypothesis: solid tumours behave as systemic metabolic dictators.Journal of cellular and molecular medicine · 2016Article
- CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury.Journal of molecular histology · 2014Article
- Enhancing adult nerve regeneration through the knockdown of retinoblastoma protein.Nature communications · 2014Article
- Dynamic changes of Jab1 and p27kip1 expression in injured rat sciatic nerve.Journal of molecular neuroscience : MN · 2013Article
- The role of C-terminal binding protein 2 in Schwann cell differentiation after sciatic nerve crush.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has been found to play an essential role in cell proliferation, but whether it was involved in Schwann cells differentiation has never been studied. We have found in sciatic nerve injury that expression of PPAR-γ decreases mainly in Schwann cells, and it was also increased in differentiated Schwann cells. Further, activated PPAR-γ by the endogenous ligand 15 d-PGJ(2) increased expressions of PPAR-γ level and Schwann cell differentiation, and this effect may be protected by its antagonist GDW9662. These results indicate that PPAR-γ could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.
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