ArticleSurgery today2012
Systemic inflammatory response syndrome as a predictor of anastomotic leakage after esophagectomy.
Article in Surgery today, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- International Society for Diseases of the Esophagus consensus on the diagnosis and treatment of anastomotic leak after esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Guideline
- Prehabilitation Reduces Occurrence of Anastomotic Leaks After Esophagectomy-A Retrospective Cohort Analysis and Meta-analysis.Journal of gastrointestinal cancer · 2025Pooled it
- Perioperative corticosteroids for reducing postoperative complications following esophagectomy: an updated systematic review and meta-analysis.BMC surgery · 2024Pooled it
- Diagnostic value of C-reactive protein to rule out infectious complications after major abdominal surgery: a systematic review and meta-analysis.International journal of colorectal disease · 2015Pooled it
- Effects of a preoperative immune-modulating diet in patients with esophageal cancer: a prospective parallel group randomized study.Langenbeck's archives of surgery · 2017Trial
- Ulinastatin, a protease inhibitor, may inhibit allogeneic blood transfusion-associated pro-inflammatory cytokines and systemic inflammatory response syndrome and improve postoperative recovery.Blood transfusion = Trasfusione del sangue · 2014Trial
- Anastomotic leakage after esophagogastric resection increases recurrence risk and impairs long-term survival - a propensity score-matched analysis.BMC surgery · 2026Article
- Review
- Systemic Inflammatory Response and the Noble and Underwood (NUn) Score as Early Predictors of Anastomotic Leakage after Esophageal Reconstructive Surgery.Journal of clinical medicine · 2024Article
- Review
- CRP as an early indicator for anastomotic leakage after esophagectomy for cancer: a single tertiary gastro-esophageal center study.Langenbeck's archives of surgery · 2023Review
- Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy.Journal of cardiothoracic surgery · 2021Article
- Prognostic value of inflammatory markers for detecting anastomotic leakage after esophageal resection.BMC surgery · 2020Article
- The perioperative presepsin as an accurate diagnostic marker of postoperative infectious complications after esophagectomy: a prospective cohort study.Esophagus : official journal of the Japan Esophageal Society · 2020Observational
- Constructing a risk prediction model for anastomotic leakage after esophageal cancer resection.The Journal of international medical research · 2020Article
- Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery.Journal of clinical medicine · 2019Review
- Early detection of complications: anastomotic leakage.Journal of thoracic disease · 2019Review
- Cancer Recurrence After Esophagectomy: Impact of Postoperative Infection in Propensity-Matched Cohorts.The Annals of thoracic surgery · 2016Article
- Rising C-reactive protein and procalcitonin levels precede early complications after esophagectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Observational
- C-reactive protein as predictor of anastomotic complications after minimally invasive oesophagectomy.Journal of minimal access surgeryArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEsophageal anastomotic leakage is still a major cause of morbidity and mortality after esophagectomy. We conducted this study to elucidate how anastomotic leakage affects the systemic inflammatory response syndrome (SIRS) criteria.
methodsThe subjects of this retrospective study were 61 patients who underwent esophagectomy. We evaluated their preoperative status, the surgical procedures, and postoperative systemic response, including white blood cell count, heart rate, respiratory rate, body temperature, and laboratory data up to postoperative day (POD) 4.
resultsAnastomotic leakage developed in nine patients (14.8%) and was found on POD 7 on average. These patients had a significantly longer hospital stay than those without leakage. Although no difference was observed in postoperative changes of any of the SIRS criteria, the postoperative incidence of SIRS was significantly higher in the patients with anastomotic leakage on POD 4. The number of positive criteria for SIRS was also significantly higher in patients with anastomotic leakage than in those without leakage on PODs 3 and 4.
conclusionsThe SIRS scoring system is valuable for evaluating the severity of systemic inflammatory response caused by anastomosis leakage, and may serve as an indicator for prompt management.
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