Trial reportEye (London, England)2012
Individualised patient care as an adjunct to standard care for promoting adherence to ocular hypotensive therapy: an exploratory randomised controlled trial.
Trial report in Eye (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multifaceted behavioral interventions to improve topical glaucoma therapy adherence in adults.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014Pooled it
- Interventions for improving adherence to ocular hypotensive therapy.The Cochrane database of systematic reviews · 2013Pooled it
- Pooled it
- The Association between Medication Adherence and Visual Field Progression in the Collaborative Initial Glaucoma Treatment Study.Ophthalmology · 2020Trial
- Using Adherence-Contingent Rebates on Chronic Disease Treatment Costs to Promote Medication Adherence: Results from a Randomized Controlled Trial.Applied health economics and health policy · 2019Trial
- Automated, Noncontact Intraocular Pressure Home Monitoring after Implantation of a Novel Telemetric Intraocular Pressure Sensor in Patients with Glaucoma: A Feasibility Study.BioMed research international · 2018Trial
- Trial
- Improving adherence to glaucoma medication: a randomised controlled trial of a patient-centred intervention (The Norwich Adherence Glaucoma Study).BMC ophthalmology · 2014Trial
- Impact of patient access to Internet health records on glaucoma medication: randomized controlled trial.Journal of medical Internet research · 2014Trial
- Protocol for a randomised controlled trial to estimate the effects and costs of a patient centred educational intervention in glaucoma management.BMC ophthalmology · 2012Trial
- Establishing Consensus on the Appropriate Tool for Measuring Adherence to Glaucoma Medication in a Sub-Saharan African Population: A Multidisciplinary Delphi-Based Study.Public health challenges · 2026Article
- Glaucoma Disease-Specific Adherence Measurement Tools Validated for Measuring Adherence to Glaucoma Medications: A Systematic Review.Health science reports · 2025Review
- The association between glaucoma treatment adherence with disease progression and loss to follow-up.Scientific reports · 2024Article
- Factors Affecting Glaucoma Medication Adherence and Interventions to Improve Adherence: A Narrative Review.Ophthalmology and therapy · 2023Review
- Medication delivery factors and adjuvant endocrine therapy adherence in breast cancer.Breast cancer research and treatment · 2023Article
- Evaluation of Compliance Issues to Anti-glaucoma Medications Before and After a Structured Interventional Program.Cureus · 2022Article
- Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafluprost/timolol fixed-dose combination therapy: 6 case reports and clinical outcomes.BMC ophthalmology · 2022Article
- The IOP lowering effects of "planning" selective laser trabeculoplasty in open angle glaucoma.Frontiers in medicine · 2022Article
- A novel EyePhone© App for improving adherence to glaucoma therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the impact of individualised patient care, as an adjunct to standard care, on adherence to ocular hypotensive therapy.
methodsA two-arm, single-masked exploratory randomised controlled trial recruited patients newly prescribed ocular hypotensive therapy. The intervention involved an individual assessment of health-care needs and beliefs and a 1-year follow-up period according to need. The primary outcome was refill adherence, measured by collating prescription and dispensing data for 12 months. Secondary outcomes included self-reported adherence, glaucoma knowledge, beliefs about illness and medicines, quality of care, intraocular pressure (IOP) fluctuation, and changes in clinical management assessed at 12 months. The strength of the intervention was measured following withdrawal by reviewing clinical outcomes for a further 12 months.
resultsIn all, 127 patients were recruited (91% response rate). Intervention-arm patients collected significantly more prescriptions than control-arm patients. Self-report adherence was significantly better in the intervention-arm for patients who forgot drops and those who intentionally missed drops. The intervention group demonstrated significantly more glaucoma knowledge, expressed a significantly stronger belief in the necessity of eye drops and believed that they had more personal control over managing their condition. Control-arm patients had more IOP fluctuation and changes in clinical management. However, this finding only reached significance at 24 months.
conclusionModelling patient care according to health-care needs and beliefs about illness and medicines can have a significant impact on improving adherence to therapy for this patient group, with the potential benefit of improving clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.