ArticleDiagnostic pathology2011
Changes of microRNAs-192, 196a and 203 correlate with Barrett's esophagus diagnosis and its progression compared to normal healthy individuals.
Article in Diagnostic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A Systematic Review of Esophageal MicroRNA Markers for Diagnosis and Monitoring of Barrett's Esophagus.Digestive diseases and sciences · 2016Pooled it
- MiR-192/NKRF axis confers lung cancer cell chemoresistance to cisplatin via the NF-κB pathway.Thoracic cancer · 2022Article
- Bile reflux and hypopharyngeal cancer (Review).Oncology reports · 2021Review
- Barrett's Esophagus and Esophageal Adenocarcinoma Biomarkers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- The temporal effects of topical NF-Oncotarget · 2020Article
- Circulating exosomal miRNAs as potential biomarkers for Barrett's esophagus and esophageal adenocarcinoma.World journal of gastroenterology · 2020Review
- NF-κB inhibition reverses acidic bile-induced miR-21, miR-155, miR-192, miR-34a, miR-375 and miR-451a deregulations in human hypopharyngeal cells.Journal of cellular and molecular medicine · 2018Article
- Bioinformatic analyses of microRNA-targeted genes and microarray-identified genes correlated with Barrett's esophagus.Cell cycle (Georgetown, Tex.) · 2018Article
- The miR-17-92 cluster as a potential biomarker for the early diagnosis of gastric cancer: evidence and literature review.Oncotarget · 2017Review
- Article
- Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression.American journal of cancer research · 2016Article
- Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray.World journal of gastroenterology · 2015Article
- MicroRNA Expression can be a Promising Strategy for the Detection of Barrett's Esophagus: A Pilot Study.Clinical and translational gastroenterology · 2014Article
- [MiR-192 confers cisplatin resistance by targeting Bim in lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Article
- Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.The EMBO journal · 2013Article
- Expression of microRNA-497 and its prognostic significance in human breast cancer.Diagnostic pathology · 2013Article
- Identification of aberrant microRNA expression pattern in pediatric gliomas by microarray.Diagnostic pathology · 2013Article
- Skewed X-chromosome inactivation in patients with esophageal carcinoma.Diagnostic pathology · 2013Article
- The expression and function of microRNA-203 in lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- The role of microRNAs in cancers of the upper gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBarrett's esophagus (BE) is a disease with a rising prevalence in western countries probably due to the unhealthy lifestyle. In significant number of cases it develops to esophageal adenocarcinoma. Two decades ago, important gene regulators (microRNAs) were discovered and their attendance in the process of malignant transformation was demonstrated (e.g. miR-192, 196a, 203). Our aim was to select the patients with the increased risk of malignant transformation before the cancer develops.
methods71 patients with BE disease were selected, slides from FFPE blocks were prepared, the lesions were microdissected and a qPCR relative expression analysis for selected microRNAs (generally known to be connected with malignant transformation process) was carried out.
resultsWe demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals.
conclusionsWe hypothesize that there do exist changes of selected microRNAs which can undoubtedly distinguish the patients with BE from normal healthy individuals.
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Registered trials
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