ArticleFEMS yeast research2011
Subcellular distribution of glutathione and its dynamic changes under oxidative stress in the yeast Saccharomyces cerevisiae.
Article in FEMS yeast research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Constructing an efficient synthesis pathway in peroxisomes to boostSynthetic and systems biotechnology · 2026Article
- Glutathione analysis and quantification in Korean supplements: method development and validation.Food science and biotechnology · 2026Article
- Adaptive laboratory evolution of Blakeslea trispora under acetoacetanilide stress leads to enhanced β-carotene biosynthesis.Scientific reports · 2025Article
- AcABI5a integrates abscisic acid signaling to developmentally modulate fruit ascorbic acid biosynthesis in kiwifruit.Horticulture research · 2025Article
- Analysis on morphological characteristics and identification of candidate genes during the flowering development of alfalfa.Frontiers in plant science · 2024Article
- Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.Molecular biology of the cell · 2024Article
- Proline, Cysteine and Branched-Chain Amino Acids in Abiotic Stress Response of Land Plants and Microalgae.Plants (Basel, Switzerland) · 2023Review
- The role of glutathione in periplasmic redox homeostasis and oxidative protein folding in Escherichia coli.Redox biology · 2023Article
- L-Ascorbic acid metabolism and regulation in fruit crops.Plant physiology · 2023Article
- Growth ability, carbon source utilization and biochemical features of the new specie Zalaria obscura.World journal of microbiology & biotechnology · 2022Article
- Yeasts collectively extend the limits of habitable temperatures by secreting glutathione.Nature microbiology · 2020Article
- Glutathione redox state plays a key role in flower development and pollen vigour.Journal of experimental botany · 2020Article
- Enzymatic improvement of mitochondrial thiol oxidase Erv1 for oxidized glutathione fermentation by Saccharomyces cerevisiae.Microbial cell factories · 2017Article
- High-glutathione producing yeasts obtained by genetic improvement strategies: a focus on adaptive evolution approaches for novel wine strains.AIMS microbiology · 2017Review
- Article
- Higher sensitivity of pad2-1 and vtc2-1 mutants to cadmium is related to lower subcellular glutathione rather than ascorbate contents.Protoplasma · 2014Article
- Regulating the redox gatekeeper: vacuolar sequestration puts glutathione disulfide in its place.Plant physiology · 2013Article
- Bioanalysis of eukaryotic organelles.Chemical reviews · 2013Review
- A central role for thiols in plant tolerance to abiotic stress.International journal of molecular sciences · 2013Review
- High resolution imaging of subcellular glutathione concentrations by quantitative immunoelectron microscopy in different leaf areas of Arabidopsis.Micron (Oxford, England : 1993) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Glutathione is an important antioxidant in most prokaryotes and eukaryotes. It detoxifies reactive oxygen species and is also involved in the modulation of gene expression, in redox signaling, and in the regulation of enzymatic activities. In this study, the subcellular distribution of glutathione was studied in Saccharomyces cerevisiae by quantitative immunoelectron microscopy. Highest glutathione contents were detected in mitochondria and subsequently in the cytosol, nuclei, cell walls, and vacuoles. The induction of oxidative stress by hydrogen peroxide (H(2) O(2) ) led to changes in glutathione-specific labeling. Three cell types were identified. Cell types I and II contained more glutathione than control cells. Cell type II differed from cell type I in showing a decrease in glutathione-specific labeling solely in mitochondria. Cell type III contained much less glutathione contents than the control and showed the strongest decrease in mitochondria, suggesting that high and stable levels of glutathione in mitochondria are important for the protection and survival of the cells during oxidative stress. Additionally, large amounts of glutathione were relocated and stored in vacuoles in cell type III, suggesting the importance of the sequestration of glutathione in vacuoles under oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.