ArticleFEMS yeast research2011
Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures.
Article in FEMS yeast research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Dry versus wet dormancy: suspended lives ofmSystems · 2026Review
- Search for the role of a Huc-type [NiFe]-hydrogenase of the soil thermophileFrontiers in microbiology · 2026Article
- Exploring Yeast's Energy Dynamics: The General Stress Response Lowers Maintenance Energy Requirement.Microbial biotechnology · 2025Article
- Characterising the metabolic rewiring of extremely slow growing Komagataella phaffii.Microbial biotechnology · 2024Article
- Microbial Growth under Limiting Conditions-Future Perspectives.Microorganisms · 2023Review
- Critical parameters and procedures for anaerobic cultivation of yeasts in bioreactors and anaerobic chambers.FEMS yeast research · 2021Article
- Real-Time Monitoring of the Yeast Intracellular State During Bioprocesses With a Toolbox of Biosensors.Frontiers in microbiology · 2021Article
- A robust flow cytometry-based biomass monitoring tool enables rapid at-line characterization of S. cerevisiae physiology during continuous bioprocessing of spent sulfite liquor.Analytical and bioanalytical chemistry · 2020Article
- Physiological responses of Saccharomyces cerevisiae to industrially relevant conditions: Slow growth, low pH, and high COBiotechnology and bioengineering · 2020Article
- Quantitative Physiology of Non-Energy-Limited Retentostat Cultures of Saccharomyces cerevisiae at Near-Zero Specific Growth Rates.Applied and environmental microbiology · 2019Article
- Diverse conditions support near-zero growth in yeast: Implications for the study of cell lifespan.Microbial cell (Graz, Austria) · 2019Review
- Yeast as a tool to identify anti-aging compounds.FEMS yeast research · 2018Review
- Close to the Edge: Growth Restrained by the NAD(P)H/ATP Formation Flux Ratio.Frontiers in microbiology · 2017Article
- Highly active promoters and native secretion signals for protein production during extremely low growth rates in Aspergillus niger.Microbial cell factories · 2016Article
- Adaptation to different types of stress converge on mitochondrial metabolism.Molecular biology of the cell · 2016Article
- Pichia pastoris Exhibits High Viability and a Low Maintenance Energy Requirement at Near-Zero Specific Growth Rates.Applied and environmental microbiology · 2016Article
- Maintenance-energy requirements and robustness of Saccharomyces cerevisiae at aerobic near-zero specific growth rates.Microbial cell factories · 2016Article
- Oxygen availability strongly affects chronological lifespan and thermotolerance in batch cultures ofMicrobial cell (Graz, Austria) · 2015Article
- Physiological and Transcriptional Responses of Different Industrial Microbes at Near-Zero Specific Growth Rates.Applied and environmental microbiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extremely low specific growth rates (below 0.01 h(-1) ) represent a largely unexplored area of microbial physiology. In this study, anaerobic, glucose-limited retentostats were used to analyse physiological and genome-wide transcriptional responses of Saccharomyces cerevisiae to cultivation at near-zero specific growth rates. While quiescence is typically investigated as a result of carbon starvation, cells in retentostat are fed by small, but continuous carbon and energy supply. Yeast cells cultivated near-zero specific growth rates, while metabolically active, exhibited characteristics previously associated with quiescence, including accumulation of storage polymers and an increased expression of genes involved in exit from the cell cycle into G(0) . Unexpectedly, analysis of transcriptome data from retentostat and chemostat cultures showed, as specific growth rate was decreased, that quiescence-related transcriptional responses were already set in at specific growth rates above 0.025 h(-1) . These observations stress the need for systematic dissection of physiological responses to slow growth, quiescence, ageing and starvation and indicate that controlled cultivation systems such as retentostats can contribute to this goal. Furthermore, cells in retentostat do not (or hardly) divide while remaining metabolically active, which emulates the physiological status of metazoan post-mitotic cells. We propose retentostat as a powerful cultivation tool to investigate chronological ageing-related processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.