ArticleDevelopmental and comparative immunology2012
Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto.
Article in Developmental and comparative immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Disease tolerance as immune defense strategy in bats: One size fits all?PLoS pathogens · 2024Review
- Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses.Viruses · 2021Review
- Studies on B Cells in the Fruit-Eating Black Flying Fox (Frontiers in immunology · 2019Article
- The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.Scientific reports · 2016Article
- Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii.Virologica Sinica · 2015Article
- Transcriptome Profiling of the Virus-Induced Innate Immune Response in Pteropus vampyrus and Its Attenuation by Nipah Virus Interferon Antagonist Functions.Journal of virology · 2015Article
- Bats as 'special' reservoirs for emerging zoonotic pathogens.Trends in microbiology · 2015Review
- Cloning, expression and antiviral activity of mink alpha-interferons.BMC veterinary research · 2015Article
- Interferon-γ Inhibits Ebola Virus Infection.PLoS pathogens · 2015Article
- Review
- Anti-lyssaviral activity of interferons κ and ω from the serotine bat, Eptesicus serotinus.Journal of virology · 2014Article
- More novel hantaviruses and diversifying reservoir hosts--time for development of reservoir-derived cell culture models?Viruses · 2014Review
- Antiviral immune responses of bats: a review.Zoonoses and public health · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats are natural reservoir hosts to a variety of viruses, many of which cause morbidity and mortality in other mammals. Currently there is a paucity of information regarding the nature of the immune response to viral infections in bats, partly due to a lack of appropriate bat specific reagents. IFNγ plays a key role in controlling viral replication and coordinating a response for long term control of viral infection. Here we describe the cloning and expression of IFNγ from the Australian flying fox, Pteropus alecto and the generation of mouse monoclonal and chicken egg yolk antibodies specific to bat IFNγ. Our results demonstrate that P. alecto IFNγ is conserved with IFNγ from other species and is induced in bat splenocytes following stimulation with T cell mitogens. P. alecto IFNγ has antiviral activity on Semliki forest virus in cell lines from P. alecto and the microbat, Tadarida brasiliensis. Additionally recombinant bat IFNγ was able to mitigate Hendra virus infection in P. alecto cells. These results provide the first evidence for an antiviral role for bat IFNγin vitro in addition to the application of important immunological reagents for further studies of bat antiviral immunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.