Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2012
African ancestry, early life exposures, and respiratory morbidity in early childhood.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Sex-specific risk factors for childhood wheeze and longitudinal phenotypes of wheeze.The Journal of allergy and clinical immunology · 2016Article
- Explaining Racial Disparities in Child Asthma Readmission Using a Causal Inference Approach.JAMA pediatrics · 2016Observational
- What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.Current allergy and asthma reports · 2016Review
- Factors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL).NPJ primary care respiratory medicine · 2016Article
- Article
- Genetic ancestry influences asthma susceptibility and lung function among Latinos.The Journal of allergy and clinical immunology · 2015Article
- Role of financial and social hardships in asthma racial disparities.Pediatrics · 2014Observational
- African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations.Genetic epidemiology · 2013Article
- No association between genetic ancestry and susceptibility to asthma or atopy in Canary Islanders.Immunogenetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundRacial disparities persist in early childhood wheezing and cannot be completely explained by known risk factors.
objectiveTo evaluate the associations of genetic ancestry and self-identified race with early childhood recurrent wheezing, accounting for socio-economic status (SES) and early life exposures.
methodsWe studied 1034 children in an urban, multi-racial, prospective birth cohort. Multivariate logistic regression was used to evaluate the association of genetic ancestry as opposed to self-identified race with recurrent wheezing (>3 episodes). Sequential models accounted for demographic, socio-economic factors and early life risk factors. Genetic ancestry, estimated using 150 ancestry informative markers, was expressed in deciles.
resultsApproximately 6.1% of subjects (mean age 3.1 years) experienced recurrent wheezing. After accounting for SES and demographic factors, African ancestry (OR: 1.16, 95% CI: 1.02-1.31) was significantly associated with recurrent wheezing. By self-reported race, hispanic subjects had a borderline decrease in risk of wheeze compared with African Americans (OR: 0.44, 95% CI: 0.19-1.00), whereas white subjects (OR: 0.46, 95% CI: 0.14-1.57) did not have. After further adjustment for known confounders and early life exposures, both African (OR: 1.19, 95% CI: 1.05-1.34) and European ancestry (OR: 0.84, 95% CI: 0.74-0.94) retained a significant association with recurrent wheezing, as compared with self-identified race (OR(whites) : 0.31, 95% CI: 0.09-1.14; OR(hispanic) : 0.47, 95% CI: 0.20-1.08). There were no significant interactions between ancestry and early life factors on recurrent wheezing. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to self-identified race, African ancestry remained a significant, independent predictor of early childhood wheezing after accounting for early life and other known risk factors associated with lung function changes and asthma. Genetic ancestry may be a powerful way to evaluate wheezing disparities and a proxy for differentially distributed genetic and early life risk factors associated with childhood recurrent wheezing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.