Evidence map›Paper›PMID 22092757›Full record

ReviewFEMS microbiology letters2011

Histoplasma mechanisms of pathogenesis--one portfolio doesn't fit all.

Jessica A Edwards, Chad A Rappleye

Open access · greenAbstract readReview
In one paragraph

Review in FEMS microbiology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. The use of genetic markers in the molecular epidemiology of histoplasmosis: a systematic review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Comparative Proteomic Analysis ofFrontiers in microbiology · 2021
    Article
  8. Article
  9. BiodiversemSphere · 2020
    Article
  10. Review
  11. Review
  12. Improved Diagnosis of Acute Pulmonary Histoplasmosis by Combining Antigen and Antibody Detection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
  13. Review
  14. Endemic Mycoses: What's New About Old Diseases?Current clinical microbiology reports · 2016
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Evolutionary Perspectives on Human Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jessica A EdwardsDepartment of Microbiology, The Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA.
Chad A Rappleye
Interface (United States) · USThe Ohio State University · US

Funding

Virulence factor discovery in the secreted proteome of Histoplasma capsulatumR01AI083335 · NIAID · OHIO STATE UNIVERSITY · PI RAPPLEYE, CHAD A · 2009 to 2012
$1.3M
NIAID NIH HHS AI083335NIAID NIH HHS R01 AI083335NIAID NIH HHS T32AI083335
6 · The paper itself

Abstract

Histoplasma capsulatum is the leading cause of endemic mycosis in the world. Analyses of clinical isolates from different endemic regions show important diversity within the species. Recent molecular studies of two isolates, the Chemotype I NAm2 strain G217B and the Chemotype II Panamanian strain G186A, reveal significant genetic, structural, and molecular differences between these representative Histoplasma strains. Some of these variations have functional consequences, representing distinct molecular mechanisms that facilitate Histoplasma pathogenesis. The realization of Histoplasma strain diversity highlights the importance of characterizing Histoplasma virulence factors in the context of specific clinical strain isolates.

Indexed as

Endemic DiseasesGenetic VariationHistoplasmaHistoplasmosisHumansVirulence FactorsVirulence Factors

Identifiers

PMID22092757
PMCPMC3228276
OpenAlexW2078428861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.