Evidence map›Paper›PMID 22092575›Full record

ReviewExperimental dermatology2011

The itchy scalp--scratching for an explanation.

Ghada A Bin Saif, Marna E Ericson, Gil Yosipovitch

Registry-linked trialAbstract readReview
In one paragraph

Review in Experimental dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04207931 (Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04207931 phase4recruitingnot on this mapstarted 2018, after this paper: background citation

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

TypeinterventionalSponsorWake Forest University Health SciencesRan2018 to 2027Enrolled250ConditionsCentral Centrifugal Cicatricial Alopecia (CCCA)ArmsTopical steroid class I-II, Triamcinolone Acetonide, Doxycyline, Minoxidil
3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Disturbed Microbial Niches of Itchy Scalp.Journal of cosmetic dermatology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Chronic itch in African Americans: an unmet need.Archives of dermatological research · 2022
    Review
  13. Pathophysiology and Treatment of Pruritus in Elderly.International journal of molecular sciences · 2020
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Efficacy of hydrophilic or lipophilic emulsions containingClinical, cosmetic and investigational dermatology · 2018
    Article
  19. [Pruritus of the scalp : Simply pulling out your hair?]Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ghada A Bin SaifDepartment of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Marna E Ericson
Gil Yosipovitch

Funding

Skin-Brain Mechanisms of Pruritus in Health and DiseaseR01AR055902 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YOSIPOVITCH, GIL · 2008 to 2011
$1.3M
NIAMS NIH HHS R01 AR055902NIAMS NIH HHS R01AR055902-03A1.NIAMS NIH HHS R0-1AR55902-3
6 · The paper itself

Abstract

Scalp pruritus is a common complaint that is considered a diagnostically and therapeutically challenging situation. Scalp skin has a unique neural structure that contains densely innervated hair follicles and dermal vasculature. In spite of the recent advances in our understanding of itch pathophysiology, scalp itching has not been studied as yet. In this review, we summarize the current knowledge on the neurobiology of scalp and hair follicles as well as itch mediators and provide a putative mechanism for scalp itch with special emphasis on neuroanatomy and pathophysiology.

Indexed as

AnimalsHumansPruritusScalpSebum

Identifiers

PMID22092575
PMCPMC3233984

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.