ArticleThe Plant journal : for cell and molecular biology2012
CDKB2 is involved in mitosis and DNA damage response in rice.
Article in The Plant journal : for cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Single-cell and spatial transcriptomics in Phragmites australis reveal the association of B chromosomes with plant invasiveness.Genome biology · 2026Article
- Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- SUPPRESSOR OF GAMMA RESPONSE 1 plays rice-specific roles in DNA damage response and repair.Plant physiology · 2023Article
- How Do Plants Cope with DNA Damage? A Concise Review on the DDR Pathway in Plants.International journal of molecular sciences · 2023Review
- Hormone analysis and candidate genes identification associated with seed size inRoyal Society open science · 2022Article
- Connections between the Cell Cycle and the DNA Damage Response in Plants.International journal of molecular sciences · 2021Review
- Plant CDKs-Driving the Cell Cycle through Climate Change.Plants (Basel, Switzerland) · 2021Review
- Article
- Defining the Cell Wall, Cell Cycle and Chromatin Landmarks in the Responses ofInternational journal of molecular sciences · 2021Article
- Article
- Generation of High Yielding and Fragrant Rice (Plants (Basel, Switzerland) · 2020Article
- Article
- OsNAC2 integrates auxin and cytokinin pathways to modulate rice root development.Plant biotechnology journal · 2020Article
- A Pelota-like gene regulates root development and defence responses in rice.Annals of botany · 2018Article
- A2-type cyclin is required for the asymmetric entry division in rice stomatal development.Journal of experimental botany · 2018Article
- Anther-preferential expressing gene PMR is essential for the mitosis of pollen development in rice.Plant cell reports · 2017Article
- The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.The EMBO journal · 2016Article
- Quantitative phosphoproteomic analysis of early seed development in rice (Oryza sativa L.).Plant molecular biology · 2016Article
- A Defect in DNA Ligase4 Enhances the Frequency of TALEN-Mediated Targeted Mutagenesis in Rice.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA damage checkpoints delay mitotic cell-cycle progression in response to DNA stress, stalling the cell cycle to allow time for repair. CDKB is a plant-specific cyclin-dependent kinase (CDK) that is required for the G₂/M transition of the cell cycle. In Arabidopsis, DNA damage leads the degradation of CDKB2, and the subsequent G₂ arrest gives cells time to repair damaged DNA. G₂ arrest also triggers transition from the mitotic cycle to endoreduplication, leading to the presence of polyploid cells in many tissues. In contrast, in rice (Oryza sativa), polyploid cells are found only in the endosperm. It was unclear whether endoreduplication contributes to alleviating DNA damage in rice (Oryza sativa). Here, we show that DNA damage neither down-regulates Orysa;CDKB2;1 nor induces endoreduplication in rice. Furthermore, we found increased levels of Orysa;CDKB2;1 protein upon DNA damage. These results suggest that CDKB2 functions differently in Arabidopsis and rice in response to DNA damage. Arabidopsis may adopt endoreduplication as a survival strategy under genotoxic stress conditions, but rice may enhance DNA repair capacity upon genotoxic stress. In addition, polyploid cells due to endomitosis were present in CDKB2;1 knockdown rice, suggesting an important role for Orysa;CDKB2;1 during mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.