ArticleDevelopmental medicine and child neurology2011
Behavioural comorbidity in Tanzanian children with epilepsy: a community-based case-control study.
Article in Developmental medicine and child neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 33 citations in OpenAlex.
- Growth parameters and childhood epilepsy in Hai District, Tanzania: a community-based study.Epilepsy research · 2014Trial
- Epilepsy phenotype and gene ontology analysis of the 129 genes in a large neurodevelopmental disorders cohort.Frontiers in neurology · 2023Article
- Behavioural and emotional comorbidities in school-aged children with neurological conditions in Kilifi, Kenya, and their long-term consequences.Global health action · 2022Article
- Co-morbidity of attention deficit hyperactivity disorder among children with seizure disorders at University of Gondar referral hospital Ethiopia (2016).Scientific reports · 2021Article
- Decentralized, primary-care delivered epilepsy services in Burera District, Rwanda: Service use, feasibility, and treatment.eNeurologicalSci · 2021Article
- Clinical characteristics of epilepsy in resource-limited communities in Punjab, Northwest India.Epilepsia open · 2020Article
- Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population.Scientific reports · 2018Article
- Prevalence, risk factors, and neurobehavioral comorbidities of epilepsy in Kenyan children.Epilepsia open · 2017Article
- Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis.Wellcome open research · 2017Article
- Cognition and behavior in a prevalent cohort of children with epilepsy in rural northern Tanzania: A three-year follow-up study.Epilepsy & behavior : E&B · 2015Article
- Community perceptions of developmental and behavioral problems experienced by children living with epilepsy on the Kenyan coast: A qualitative study.Epilepsy & behavior : E&B · 2015Article
- Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa.The Lancet. Neurology · 2014Review
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9 authors at 5 institutions in 2 countries.
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Abstract
aimThe aim of this study was to define the prevalence of and risk factors for behavioural disorders in children with epilepsy from a rural district of Tanzania by conducting a community-based case-control study.
methodOne hundred and twelve children aged 6 to 14 years (55 males, 57 females; median age 12 y) with active epilepsy (at least two unprovoked seizures in the last 5 y) were identified in a cross-sectional survey and included in this study. Children who were younger than 6 years were excluded in order to eliminate febrile seizures. Behaviour was assessed using the Rutter scale; children who scored 13 or more were considered to have disordered behaviour. A comparison group was made up of age- and sex-matched children without epilepsy (n = 113; 57 males, 56 females; median age 12 y).
resultsBehavioural disorders were diagnosed in 68 of 103 (66%) children with epilepsy and in 19 of 99 (19%) controls. Disordered behaviour was significantly more common in children with epilepsy than in the comparison group (univariate odds ratio 8.2; 95% confidence interval [CI] 4.3-15.6; p < 0.001) and frequent seizures and poor scholastic attainment were associated in children with epilepsy. Behavioural disorders were not associated with antiepileptic drug usage. Attention problems were present in 48 of 91 (53%) children with epilepsy and 16 of 97 (17%) controls (univariate odds ratio 5.7; 95% CI 2.9-11.1; p < 0.001). In children with epilepsy, attention problems were significantly more common in males and were associated with frequent seizures.
interpretationChildren with epilepsy in a rural area of sub-Saharan Africa have a high prevalence of behavioural disorders and attention problems, both of which are associated with frequent seizures. Providing behaviour assessment and appropriate intervention programmes for children with epilepsy may reduce the burden of behaviour disorders in this setting.
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