Trial reportJournal of the American Geriatrics Society2011
Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.
Trial report in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00586196 (Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period), which is not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Global evaluation of the impact of nursing interventions on rehabilitation in older patients following fracture.BMC geriatrics · 2026Pooled it
- Cholinesterase inhibitors for the treatment of delirium in non-ICU settings.The Cochrane database of systematic reviews · 2018Pooled it
- Acetylcholinesterase Inhibitors for Delirium in Older Adults.American journal of Alzheimer's disease and other dementias · 2016Pooled it
- Interventions for preventing delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2016Pooled it
- Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials.Critical care (London, England) · 2013Pooled it
- Design considerations of a randomized controlled trial of sedation level during hip fracture repair surgery: a strategy to reduce the incidence of postoperative delirium in elderly patients.Clinical trials (London, England) · 2017Trial
- Cholinergic regulation of neuroinflammation: linking microglia, immunometabolism, and neuromodulation.Frontiers in immunology · 2026Review
- Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles.International journal of nanomedicine · 2024Article
- Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Reexamining cholinesterase inhibitors for the prevention and treatment of delirium in high-risk populations.Critical care (London, England) · 2023Article
- Preventing and treating delirium in clinical settings for older adults.Therapeutic advances in psychopharmacology · 2023Review
- Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis.Scientific reports · 2021Article
- Delirium.Nature reviews. Disease primers · 2020Review
- Approach to Cognitive Impairment in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Delirium Management in the ICU.Current treatment options in neurology · 2019Review
- Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).Acute medicine & surgery · 2018Article
- The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).Journal of intensive care · 2018Article
- Review
- Intensive Care Unit Delirium: A Review of Diagnosis, Prevention, and Treatment.Anesthesiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair.
designPilot double-masked randomized placebo-controlled trial.
settingLarge academic medical center.
participantsSixteen individuals aged 70 and older with hip fracture.
interventionDonepezil 5 mg or placebo was randomly allocated and initiated within 24 hours of surgery, preoperatively or postoperatively. Daily treatment was continued for 30 days or until side effects or the clinical situation required termination. MEASUREMENTS: All outcomes were ascertained masked to treatment status. Information on drug tolerability and safety was obtained from the participant, nurse, and medical record. Delirium presence and severity were measured during daily hospital interviews and at 2, 4, and 6 weeks after surgery after a standardized assessment using the Confusion Assessment Method (CAM) and the Memorial Delirium Assessment Scale (MDAS).
resultsParticipants in the donepezil and placebo arms had similar baseline characteristics. Participants in the donepezil arm experienced significantly more side effects. In longitudinal models, there were no significant differences between the donepezil and placebo arms with regard to delirium presence over time (odds ratio = 0.9, 95% confidence interval (CI) = 0.4-2.3) or delirium severity over time (effect size = -0.2 on 30-point MDAS scale, 95%CI = -1.5-1.2).
conclusionParticipants randomized to donepezil had no significant improvement in delirium presence or severity but experienced more side effects. Overall, sufficient evidence was not found from this pilot study to warrant a definitive Phase III trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.