ArticleMolecular biology international2011
The Role of miRNAs as Key Regulators in the Neoplastic Microenvironment.
Article in Molecular biology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review.Molecular biology reports · 2021Pooled it
- miR-6850 drives phenotypic changes and signaling in high grade serous ovarian cancer.Non-coding RNA research · 2026Article
- Exosomal regulation of cellular reprogramming and polarization in the tumor microenvironment.Cancer cell international · 2025Review
- The Epigenetic Regulation of Microenvironment in Hepatocellular Carcinoma.Frontiers in oncology · 2021Review
- A Strong Decrease inFrontiers in oncology · 2019Article
- Emerging role of RUNX3 in the regulation of tumor microenvironment.BMB reports · 2018Review
- Tumour-suppressive microRNA-424-5p directly targets CCNE1 as potential prognostic markers in epithelial ovarian cancer.Cell cycle (Georgetown, Tex.) · 2018Article
- Regulatory mechanisms of microRNA expression.Journal of translational medicine · 2016Review
- MicroRNAs Associated with Shoulder Tendon Matrisome Disorganization in Glenohumeral Arthritis.PloS one · 2016Article
- MicroRNA regulons in tumor microenvironment.Oncogene · 2015Review
- MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3α.BMC cancer · 2014Article
- MicroRNA and Epigenetics: Diagnostic and Therapeutic Opportunities.Current pathobiology reports · 2013Article
- miR-29b moulds the tumour microenvironment to repress metastasis.Nature cell biology · 2013Article
- Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma.PloS one · 2013Article
- Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis.OncoTargets and therapy · 2013Review
- A microRNA component of the neoplastic microenvironment: microregulators with far-reaching impact.BioMed research international · 2013Review
- Article
- Nucleic acids in circulation: are they harmful to the host?Journal of biosciences · 2012Review
- Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer.Biomolecular concepts · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neoplastic microenvironment has been recognized to play a critical role in the development of cancer. Although a large body of evidence has established the importance of the cancer microenvironment, the manners of crosstalk between it and the cancer cells still remains unclear. Emerging mechanisms of communication include microRNAs (miRNAs). miRNAs are small noncoding RNA molecules that are involved in the posttranscriptional regulation of mRNA. Both intracellular and circulating miRNAs are differentially expressed in cancer and some of these alterations have been correlated with clinical patient outcomes. The role of miRNAs in the tumor microenvironment has only recently become a focus of research, however. In this paper, we discuss the influence of miRNAs on the tumor microenvironment as it relates to cancer progression. We conclude that miRNAs are a critical component in understanding invasion and metastasis of cancer cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.