ArticleMolecular biology international2011
Protein methylation and stress granules: posttranslational remodeler or innocent bystander?
Article in Molecular biology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.Essays in biochemistry · 2025Review
- Metal-polyphenol-network coated R612F nanoparticles reduce drug resistance in hepatocellular carcinoma by inhibiting stress granules.Cell death discovery · 2024Article
- RNA-Binding Proteins: A Role in Neurotoxicity?Neurotoxicity research · 2023Review
- Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.Amino acids · 2023Article
- Stress Granules in Cancer.Reviews of physiology, biochemistry and pharmacology · 2023Article
- Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity.Frontiers in cellular neuroscience · 2023Article
- Protein arginine methylation in transcription and epigenetic regulation.Frontiers in epigenetics and epigenomics · 2023Review
- Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD.Frontiers in cellular neuroscience · 2021Article
- Molecular mechanisms of stress granule assembly and disassembly.Biochimica et biophysica acta. Molecular cell research · 2021Review
- The Role of RNA in Biological Phase Separations.Journal of molecular biology · 2018Review
- Interaction modulation through arrays of clustered methyl-arginine protein modifications.Life science alliance · 2018Article
- Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.Nucleic acids research · 2018Article
- Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.Cell discovery · 2017Article
- Review
- New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Chemical reviews · 2015Review
- FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress.Journal of cellular physiology · 2013Article
- Protein arginine methyltransferases and cancer.Nature reviews. Cancer · 2013Review
- Arginylated calreticulin at plasma membrane increases susceptibility of cells to apoptosis.The Journal of biological chemistry · 2012Article
- Regulation of stress granules in virus systems.Trends in microbiology · 2012Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.